{"id":"W3043529679","doi":"10.1021/acsomega.0c01764","title":"Novel Poly(vinylpyrrolidone)-Coated Silicone Contact Lenses to Improve Tear Volume During Lens Wear: In Vitro and In Vivo Studies","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Polyvinylpyrrolidone; Contact lens; Eye drop; Materials science; Swelling; In vivo; Bioavailability; Silicone; Swelling capacity; Contact angle; Biomedical engineering; Ophthalmology; Composite material; Medicine; Pharmacology; Polymer chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002667941,0.0004881116,0.0003139294,0.0002284681,0.0001130097,0.00024792,0.000238612,0.0002791414,0.0004850388],"category_scores_gemma":[0.0002602333,0.0001572232,0.0003684869,0.0001925746,0.0001662607,0.0003767095,0.0001269131,0.0003689625,0.00011441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002329667,"about_ca_system_score_gemma":0.0001912346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036652,"about_ca_topic_score_gemma":0.00166288,"domain_scores_codex":[0.9998222,0.00002163748,0.00001438672,0.00003951883,0.00006943632,0.0000327299],"domain_scores_gemma":[0.9998125,0.0000442081,0.00005839712,0.00001278847,0.00003802844,0.00003407372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001910165,0.0001057579,0.00008513749,0.0001339189,0.00001091307,0.00004257704,0.00001841399,0.00009367946,0.9967718,0.00001500887,0.0000281306,0.002503564],"study_design_scores_gemma":[0.00004810283,0.00388415,0.003505154,0.000007042807,0.00004720304,0.0001535867,0.00002369038,0.000839748,0.990294,0.000009321309,0.00117589,0.0000122199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880152,0.006243816,0.004737566,0.0000652354,0.00007503344,0.00008897891,0.0001916865,0.00006386294,0.0005185362],"genre_scores_gemma":[0.9870767,0.004311044,0.006724245,0.00005816453,0.0000283065,0.00007129355,0.0001894452,0.00002244197,0.001518273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036652,"threshold_uncertainty_score":0.002061248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02309681652766923,"score_gpt":0.2608138575570487,"score_spread":0.2377170410293795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}