{"id":"W3043558604","doi":"10.34172/ps.2020.11","title":"Overexpression of ABCC2 and NF-Κβ/p65 with Reduction in Cisplatin and 4OH-Tamoxifen Sensitivity in MCF-7 Breast Cancer Cells: The Influence of TNF-α","year":2020,"lang":"en","type":"article","venue":"Pharmaceutical Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Multidrug resistance-associated protein 2; MCF-7; Estrogen receptor; Tamoxifen; MTT assay; Tumor necrosis factor alpha; Viability assay; Western blot; ATP-binding cassette transporter; Internal medicine; Pharmacology; Cancer research; Cancer cell; Breast cancer; Medicine; Chemistry; Endocrinology; Cell growth; Cancer; Transporter; Cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004311464,0.00008183922,0.0001939095,0.00004159495,0.00004239628,0.000006919621,0.0000494635,0.00003297285,0.00001848093],"category_scores_gemma":[0.00001391496,0.00004501523,0.0000131727,0.000419056,0.0006765377,0.0001246679,0.00002493093,0.0001549146,1.637623e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001140188,"about_ca_system_score_gemma":0.00006428108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002974379,"about_ca_topic_score_gemma":0.0001119463,"domain_scores_codex":[0.9990985,0.00004725931,0.0001837937,0.0002259217,0.0002906016,0.0001539433],"domain_scores_gemma":[0.9996911,0.00006277663,0.00006273964,0.00005065015,0.00003188655,0.0001009058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005201176,0.0000583894,0.1243325,0.0002056502,0.000004958781,0.00001098564,0.001306076,0.0007322817,0.8693162,0.0001354553,0.000004305993,0.003373105],"study_design_scores_gemma":[0.001199472,0.0001491093,0.6509379,0.0007508519,0.00003869425,0.00003029651,0.0008054406,0.007703605,0.3381226,0.000120738,0.00004373937,0.00009762908],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956551,0.0002454051,0.00001957372,0.003717192,0.00001956071,0.0002139542,0.00001142992,0.000005784001,0.0001120567],"genre_scores_gemma":[0.999249,0.0003385697,0.0002089321,0.0001689813,0.00002170661,0.000004439487,3.543843e-7,0.000003165977,0.000004872086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5311936,"threshold_uncertainty_score":0.2492731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0297557120269241,"score_gpt":0.3225555623875984,"score_spread":0.2927998503606743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}