{"id":"W3043558604","doi":"10.34172/ps.2020.11","title":"Overexpression of ABCC2 and NF-Κβ/p65 with Reduction in Cisplatin and 4OH-Tamoxifen Sensitivity in MCF-7 Breast Cancer Cells: The Influence of TNF-α","year":2020,"lang":"en","type":"article","venue":"Pharmaceutical Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Multidrug resistance-associated protein 2; MCF-7; Estrogen receptor; Tamoxifen; MTT assay; Tumor necrosis factor alpha; Viability assay; Western blot; ATP-binding cassette transporter; Internal medicine; Pharmacology; Cancer research; Cancer cell; Breast cancer; Medicine; Chemistry; Endocrinology; Cell growth; Cancer; Transporter; Cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000232895,0.00031856,0.0004220003,0.0002519094,0.0001950298,0.0003345458,0.0001469546,0.0003030049,0.001711241],"category_scores_gemma":[0.0001361688,0.0001684554,0.0004405269,0.0002928612,0.0003084677,0.000203616,0.0001403354,0.0006201849,0.0004865791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002455349,"about_ca_system_score_gemma":0.0002270291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008547173,"about_ca_topic_score_gemma":0.001057467,"domain_scores_codex":[0.9997272,0.00003256611,0.00003149425,0.00004626208,0.00008954353,0.00007294619],"domain_scores_gemma":[0.9998491,0.00002262905,0.00003802773,0.00002085621,0.00003134371,0.00003810026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000203438,0.00006359397,0.0002504563,0.00006454334,0.00000803889,0.00006569488,0.00003242482,0.00002533739,0.9986399,0.00002987636,0.00005796331,0.0005587378],"study_design_scores_gemma":[0.0000302112,0.0009151748,0.006691932,0.0000133425,0.00003645525,0.0004028259,0.0001284525,0.000637918,0.9880049,0.00003258463,0.003097412,0.000008634224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898212,0.00516535,0.002003051,0.000283801,0.0001459268,0.00003942876,0.0007939336,0.00008279592,0.001664507],"genre_scores_gemma":[0.9890934,0.002357665,0.002402712,0.0001215974,0.000033176,0.0001060307,0.001380785,0.00001767666,0.004487054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001711241,"threshold_uncertainty_score":0.005724728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0297557120269241,"score_gpt":0.3225555623875984,"score_spread":0.2927998503606743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}