{"id":"W3043577596","doi":"10.1158/1538-7445.pedca19-pr11","title":"Abstract PR11: EP300 controls the oncogenic enhancer landscape of high-risk neuroblastoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biology; Histone acetyltransferase; Acetylation; Enhancer; Cancer research; Cereblon; Histone; CREB-binding protein; Neuroblastoma; P300-CBP Transcription Factors; Cell biology; Genetics; Gene; Transcription factor; Ubiquitin; Histone Acetyltransferases; Cell culture; Ubiquitin ligase","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199772,0.0002717423,0.0001913975,0.0001646831,0.0001619507,0.0003309585,0.0004036883,0.0002871712,0.0039448],"category_scores_gemma":[0.0001591004,0.0001441932,0.0001824094,0.000115807,0.000324157,0.0001780337,0.0003279405,0.0009665709,0.001198716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004791786,"about_ca_system_score_gemma":0.0002817753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001249965,"about_ca_topic_score_gemma":0.001971195,"domain_scores_codex":[0.9998361,0.00001568211,0.00001378296,0.0000465205,0.0000539602,0.00003385394],"domain_scores_gemma":[0.9998763,0.0000183854,0.00003258448,0.00001319768,0.00001466047,0.00004499734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001135848,0.00002124531,0.0002047717,0.00002578066,0.000002627315,0.00006240553,0.000005580586,0.0000606477,0.9978313,0.000135887,0.00009900215,0.001437176],"study_design_scores_gemma":[0.00003679397,0.0001879807,0.008769791,0.000007179619,0.00001425207,0.0004445373,0.00003940526,0.002169844,0.9839707,0.00009106369,0.004259674,0.000008659482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811654,0.001388797,0.01019965,0.000254054,0.0001004971,0.00005103006,0.001530028,0.0003899536,0.004920577],"genre_scores_gemma":[0.991307,0.0003595855,0.001721193,0.0000855886,0.000006824847,0.00002657918,0.0008525618,0.00005900009,0.005581711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0039448,"threshold_uncertainty_score":0.01319671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05843736545061853,"score_gpt":0.3805619475683922,"score_spread":0.3221245821177737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}