{"id":"W3043592986","doi":"10.3390/vaccines8030392","title":"Generation of a Peptide Vaccine Candidate against Falciparum Placental Malaria Based on a Discontinuous Epitope","year":2020,"lang":"en","type":"article","venue":"Vaccines","topic":"Malaria Research and Control","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Medical Research Council; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; University of Queensland; National Institutes of Health; University of Alberta","keywords":"Epitope; Biology; Virology; Heterologous; Malaria vaccine; Keyhole limpet hemocyanin; Monoclonal antibody; Peptide; Peptide vaccine; Plasmodium falciparum; Antibody; Antigen; Computational biology; Malaria; Immunology; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001129805,0.0003282543,0.000211915,0.0001757907,0.00008709118,0.0002227682,0.0002377223,0.0002541729,0.0009240161],"category_scores_gemma":[0.0001189479,0.0001274889,0.0001550813,0.0001295528,0.0001501585,0.0001448976,0.0002395014,0.0004266792,0.0002936076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001923648,"about_ca_system_score_gemma":0.0001975695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001593331,"about_ca_topic_score_gemma":0.0002479912,"domain_scores_codex":[0.9999516,0.000008358393,0.000003273187,0.00001100384,0.0000127603,0.00001303294],"domain_scores_gemma":[0.9999557,0.00000681349,0.00001170757,0.000003989741,0.000006389539,0.00001538247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007924444,0.00005723571,0.0001727072,0.00005250676,0.00000535378,0.0001130582,0.00001498532,0.00081518,0.9943123,0.0002819514,0.00006732807,0.004028099],"study_design_scores_gemma":[0.0001979908,0.002503962,0.002303347,0.00002228975,0.00004105645,0.0007527142,0.00004274238,0.007999636,0.9742138,0.0003066635,0.01160205,0.00001375675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876338,0.0008896636,0.009993842,0.000102912,0.00004971574,0.00008726499,0.0001430243,0.00004877154,0.001051009],"genre_scores_gemma":[0.9878497,0.0008457033,0.008943011,0.0000702658,0.00001748554,0.00006094072,0.0004041703,0.00001233902,0.001796521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009240161,"threshold_uncertainty_score":0.003091156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02943670937294683,"score_gpt":0.2763057705867599,"score_spread":0.2468690612138131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}