{"id":"W3043659712","doi":"10.1016/j.ceca.2020.102253","title":"PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection","year":2020,"lang":"en","type":"article","venue":"Cell Calcium","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; University of British Columbia; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Downregulation and upregulation; Inflammation; Purinergic receptor; Cell biology; Mechanism (biology); Tumor necrosis factor alpha; Neuroscience; Biology; Immunology; Extracellular; Physics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006613334,0.0001078528,0.0001418497,0.00009019262,0.0001079402,0.00001689483,0.00004628576,0.0001444051,0.00002931565],"category_scores_gemma":[0.00004624972,0.00009477747,0.00002420581,0.0001358006,0.00003128895,0.0001517779,0.0000229808,0.0001175955,0.00007768018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000306617,"about_ca_system_score_gemma":0.00008682778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006983776,"about_ca_topic_score_gemma":0.00003324096,"domain_scores_codex":[0.9993783,0.00006360064,0.0002056725,0.0001886092,0.00001445442,0.0001494181],"domain_scores_gemma":[0.9996645,0.00007126275,0.00007686604,0.000109723,0.00005049847,0.00002718778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000528576,0.00001355265,0.000563845,0.00004728537,0.00001472085,2.32679e-7,0.001020688,0.00001427891,0.9861476,0.002921724,0.001012499,0.007714982],"study_design_scores_gemma":[0.001919509,0.000588822,0.02092336,0.00002361202,0.00004261574,0.000008436099,0.00007694257,0.0001180515,0.9210954,0.001369972,0.0536364,0.0001968778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620249,0.0005503623,0.03411924,0.002028734,0.0001764169,0.0006410669,0.000005836534,0.00007052642,0.0003829615],"genre_scores_gemma":[0.9988164,0.00006609895,0.00009918906,0.0001561212,0.00005487541,0.00006944023,0.0001601712,0.00001254433,0.0005651469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06505221,"threshold_uncertainty_score":0.3864913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02528378619418999,"score_gpt":0.2541248868940852,"score_spread":0.2288411006998953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}