{"id":"W3043665451","doi":"10.1038/s42255-020-0231-8","title":"DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes","year":2020,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Epigenetics; Type 1 diabetes; DNA methylation; Diabetes mellitus; Medicine; Enhancer; Endocrinology; Internal medicine; Bioinformatics; Biology; Transcription factor; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002253203,0.0001048465,0.0001729898,0.00005416449,0.00003439588,0.00000741045,0.0001305006,0.0002754935,0.00001002164],"category_scores_gemma":[0.0005199654,0.0001012479,0.0000401207,0.0003116739,0.0000232819,0.000003648757,0.00005166113,0.0001579841,0.000004611105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008141289,"about_ca_system_score_gemma":0.00007593998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001496322,"about_ca_topic_score_gemma":0.00002588101,"domain_scores_codex":[0.9991517,0.00007187083,0.000278185,0.0002170465,0.0001454089,0.0001357587],"domain_scores_gemma":[0.9994785,0.00002491539,0.0001308999,0.0001314755,0.0001761656,0.00005801013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001150629,0.00004191124,0.005943867,0.000010883,0.00003903986,7.727942e-8,0.0002653552,0.00007033075,0.9877447,0.0001767184,0.00009320769,0.005602409],"study_design_scores_gemma":[0.0002850055,0.00002369574,0.2174274,0.000005731621,0.00001487658,1.566475e-8,0.00001590504,0.0001207721,0.7533234,0.0002164593,0.02846492,0.00010178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834645,0.01507391,0.0003199154,0.0004687657,0.0001435801,0.0001407184,0.00001450872,0.000009805929,0.0003642857],"genre_scores_gemma":[0.9954002,0.0002473851,0.003525752,0.0002410236,0.00008986109,0.00001046779,0.0004556311,0.00001390337,0.00001574408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2344213,"threshold_uncertainty_score":0.4128768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01374738480179624,"score_gpt":0.2657881631835273,"score_spread":0.2520407783817311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}