{"id":"W3043674480","doi":"10.1038/s43018-020-0094-7","title":"Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma","year":2020,"lang":"en","type":"article","venue":"Nature Cancer","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Institute for Research in Immunology and Cancer; McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Medical Research Council; Canadian Institutes of Health Research","keywords":"Sonic hedgehog; Biology; Loss of heterozygosity; PTCH1; Cancer research; DNA replication; Carcinogenesis; DNA repair; Genetics; Cell biology; Cancer; DNA; Allele; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001934903,0.0002596313,0.000204817,0.0006734023,0.0003241202,0.000307163,0.0002961674,0.000235726,0.001550591],"category_scores_gemma":[0.0002034334,0.0002888415,0.0002904448,0.0002556369,0.0002590382,0.0002943094,0.0002534116,0.0005563874,0.0003623366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000765316,"about_ca_system_score_gemma":0.0004325113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008586691,"about_ca_topic_score_gemma":0.008750685,"domain_scores_codex":[0.9998586,0.00002768389,0.00001291109,0.00002041664,0.00003146986,0.00004892585],"domain_scores_gemma":[0.9998674,0.00002874404,0.00002532389,0.00002063797,0.00001648326,0.00004150293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002928778,0.00002004199,0.000646201,0.00002409226,0.000006536846,0.00008258082,0.00002342149,0.00007732467,0.9977532,0.0002250016,0.00006406211,0.0007847782],"study_design_scores_gemma":[0.000008663562,0.0001321003,0.006251641,0.000002216718,0.000009593219,0.0001364232,0.00003714077,0.0004532402,0.9919709,0.00005100703,0.0009444846,0.000002669485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933479,0.001760551,0.002226162,0.0001386022,0.0000382678,0.00003242234,0.0005749645,0.0001092859,0.001771751],"genre_scores_gemma":[0.9957275,0.0005713923,0.001087922,0.00001738018,0.000009481595,0.00001464248,0.0003066997,0.00002155838,0.002243422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008586691,"threshold_uncertainty_score":0.01707345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03268470185520939,"score_gpt":0.3426323914873363,"score_spread":0.3099476896321269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}