{"id":"W3043767842","doi":"10.1101/2020.07.14.203232","title":"Drug Screening Platform Using Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes and Optical Mapping","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia; BC Children's Hospital; Simon Fraser University","funders":"Canadian Institutes of Health Research; Stem Cell Network","keywords":"Induced pluripotent stem cell; Retinoic acid; Transcriptome; Drug; Atrial fibrillation; Pharmacology; Wnt signaling pathway; Medicine; Chemistry; Internal medicine; Signal transduction; Gene; Gene expression; Biochemistry; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003804904,0.0008555831,0.0009132525,0.0004092902,0.0006607771,0.0007321108,0.0008837662,0.0003801141,0.000004743723],"category_scores_gemma":[0.0002390446,0.0009296024,0.000328355,0.0007861478,0.0002206673,0.0005204104,0.001687128,0.001588446,0.00001150689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000203597,"about_ca_system_score_gemma":0.0002616284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004532065,"about_ca_topic_score_gemma":4.257498e-7,"domain_scores_codex":[0.9952201,0.0001388312,0.0007780739,0.002052127,0.0008248136,0.0009860983],"domain_scores_gemma":[0.9977878,0.0001885565,0.0004288203,0.0008563616,0.0001038502,0.0006345613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002635014,0.00002173301,0.0001756188,0.000282999,0.00002064373,0.0003081444,0.00003694949,0.0007047383,0.9982617,0.0001470654,0.000004684393,0.000009406299],"study_design_scores_gemma":[0.0007100624,0.00004747084,0.001747566,0.0003244006,0.00009017392,3.127704e-7,0.00001809373,0.01577963,0.9801593,0.000001424536,0.0001442748,0.000977266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941261,0.0002087418,0.002357901,0.0001444455,0.001526279,0.0009047036,0.00005734129,0.0006678618,0.000006615979],"genre_scores_gemma":[0.9959788,0.00009477812,0.002622254,0.000233895,0.0008577593,0.00003443381,9.542079e-8,0.0001761287,0.000001821568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01810235,"threshold_uncertainty_score":0.9993154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06975953431268346,"score_gpt":0.2468821083379642,"score_spread":0.1771225740252808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}