{"id":"W3043773677","doi":"10.1158/1538-7445.pedca19-pr07","title":"Abstract PR07: GD2 is a macrophage checkpoint molecule and combined GD2/CD47 blockade results in synergistic effects and tumor clearance in xenograft models of neuroblastoma and osteosarcoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CD47; Blockade; Medicine; Cancer research; Antibody; Neuroblastoma; Monoclonal antibody; Osteosarcoma; Phagocytosis; Immunotherapy; In vivo; Radioimmunotherapy; Macrophage; Cancer; Pharmacology; Immunology; In vitro; Internal medicine; Chemistry; Cell culture; Receptor; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002534619,0.0005360206,0.0005457017,0.0002698926,0.0001437806,0.0002396323,0.0002509079,0.0003714141,0.001430426],"category_scores_gemma":[0.00006487827,0.0001575776,0.0004145571,0.0001742801,0.0002248709,0.0002226992,0.0001554352,0.001158773,0.0003324493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003756993,"about_ca_system_score_gemma":0.000431946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001209231,"about_ca_topic_score_gemma":0.00214715,"domain_scores_codex":[0.9997299,0.00004704409,0.00002177471,0.00004104166,0.0000800169,0.00008015293],"domain_scores_gemma":[0.9998962,0.00001316646,0.00001505531,0.00001250202,0.00001302332,0.00005012721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008041266,0.0004308836,0.0001526385,0.000054425,0.0000218553,0.00004275091,0.00001320181,0.0002030323,0.9958625,0.0001166956,0.0003273894,0.001970429],"study_design_scores_gemma":[0.00008751344,0.002892899,0.001151623,0.000003285902,0.00002761533,0.000115578,0.00001544402,0.001186237,0.9927523,0.00001966368,0.001743741,0.000004198278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932737,0.001388606,0.002044046,0.0001951008,0.0001337123,0.00007059887,0.0004846094,0.0001235677,0.002286023],"genre_scores_gemma":[0.9908813,0.0006236415,0.003203108,0.0001036998,0.00002312306,0.00009601678,0.0008531948,0.00003011674,0.004185786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001430426,"threshold_uncertainty_score":0.00478524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04383254322733609,"score_gpt":0.3449037828000689,"score_spread":0.3010712395727328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}