{"id":"W3043806255","doi":"10.1021/acs.jmedchem.0c01025","title":"Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting","year":2020,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Research Chairs; Ontario Research Foundation; Canada Foundation for Innovation; Canadian Cancer Society","keywords":"HDAC8; Chemistry; In vitro; Stereochemistry; Histone; Biochemistry; Histone deacetylase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001939213,0.0003775067,0.0003049533,0.00009676838,0.0001220019,0.0002336051,0.0003516384,0.0002172764,0.001622118],"category_scores_gemma":[0.0002814783,0.0001432489,0.000195425,0.0001142181,0.0001476943,0.0001816954,0.0001396634,0.0003695845,0.0004917493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003945448,"about_ca_system_score_gemma":0.0002344597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008109798,"about_ca_topic_score_gemma":0.001821099,"domain_scores_codex":[0.9998927,0.00001979431,0.000006630637,0.00001986059,0.0000362824,0.0000247444],"domain_scores_gemma":[0.9999225,0.00001763709,0.00002161172,0.000006763577,0.00001389741,0.00001756642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003641019,0.0002158187,0.0002734891,0.0002424877,0.00002617719,0.0001339488,0.00004571622,0.009557884,0.9776598,0.0009536051,0.0004111432,0.01011586],"study_design_scores_gemma":[0.0001783121,0.001917481,0.0009736545,0.00002101325,0.0000280206,0.0001707868,0.0000324558,0.01078742,0.9790958,0.0001259288,0.006641124,0.00002801525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826803,0.002772414,0.008487121,0.0001323206,0.00003661677,0.0002165409,0.0005790135,0.0001345721,0.004961119],"genre_scores_gemma":[0.98667,0.001847293,0.008107318,0.00007159695,0.0000125039,0.0001115927,0.0007932194,0.00003420046,0.002352254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001622118,"threshold_uncertainty_score":0.005426526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009670487799964175,"score_gpt":0.2535356737868937,"score_spread":0.2438651859869296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}