{"id":"W3043818052","doi":"10.1158/1078-0432.ccr-20-1170","title":"Talimogene Laherparepvec and Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY-232): A Multicenter, Phase 1b Study","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Rosetrees Trust; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Amgen","keywords":"Medicine; Pembrolizumab; Head and neck; Head and neck squamous-cell carcinoma; Oncology; Basal cell; Head and neck cancer; Internal medicine; Radiology; Pathology; Cancer research; Cancer; Immunotherapy; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00203557,0.001226826,0.001482899,0.000370466,0.000307026,0.0007497357,0.0008851789,0.0008007708,0.00254404],"category_scores_gemma":[0.0006744768,0.0005249235,0.001130312,0.0003051679,0.0007093928,0.0006473754,0.0002622388,0.00187172,0.0006217041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009624729,"about_ca_system_score_gemma":0.001569856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001292326,"about_ca_topic_score_gemma":0.003058033,"domain_scores_codex":[0.9996011,0.0001985166,0.00001858726,0.00005797961,0.00005006575,0.00007384039],"domain_scores_gemma":[0.9994873,0.00007225372,0.0001145904,0.00003827406,0.00003077452,0.0002567971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6197072,0.145116,0.01887398,0.001626479,0.003466654,0.0003610583,0.000455511,0.002428952,0.07427756,0.00025927,0.005328549,0.1280989],"study_design_scores_gemma":[0.4175217,0.549715,0.02170728,0.00004723696,0.00111211,0.0003358657,0.00008139507,0.00105764,0.006041899,0.0001006398,0.002250987,0.0000282523],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966994,0.001570517,0.0001048541,0.0001486584,0.00003986699,0.0006515092,0.0002278684,0.00002469169,0.00053262],"genre_scores_gemma":[0.9939832,0.001601099,0.0005457259,0.0004708958,0.0001446573,0.0008781822,0.000873825,0.00001369342,0.001488757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00254404,"threshold_uncertainty_score":0.01076525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2267127426001978,"score_gpt":0.5082349306894123,"score_spread":0.2815221880892145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}