{"id":"W3043818052","doi":"10.1158/1078-0432.ccr-20-1170","title":"Talimogene Laherparepvec and Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY-232): A Multicenter, Phase 1b Study","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Rosetrees Trust; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Amgen","keywords":"Medicine; Pembrolizumab; Head and neck; Head and neck squamous-cell carcinoma; Oncology; Basal cell; Head and neck cancer; Internal medicine; Radiology; Pathology; Cancer research; Cancer; Immunotherapy; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001632527,0.0001854847,0.0003909919,0.0000675612,0.0001100406,0.00003866187,0.0004757544,0.00009761596,0.00006610011],"category_scores_gemma":[0.0007561523,0.000127931,0.00009244871,0.0003914327,0.0005325502,0.000006512953,0.000752769,0.000593807,0.000003104672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003484699,"about_ca_system_score_gemma":0.000505975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003728922,"about_ca_topic_score_gemma":0.003994268,"domain_scores_codex":[0.9959794,0.001614603,0.0006285842,0.0007384903,0.0005461293,0.0004927433],"domain_scores_gemma":[0.9985376,0.00028205,0.0001036622,0.0005397134,0.0002143218,0.000322682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2297846,0.01588625,0.4543096,0.001038708,0.0002652393,0.0002259954,0.003125164,0.00004553269,0.1759498,0.000002923645,0.00201275,0.1173534],"study_design_scores_gemma":[0.1978562,0.2902174,0.1264571,0.0002576621,0.0002152735,0.00002110041,0.006166367,0.005721746,0.3603839,0.00004426837,0.01139766,0.001261329],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908168,0.006721794,0.000003126383,0.0007665032,0.00006671418,0.00147984,0.0000858835,0.000003959708,0.00005539668],"genre_scores_gemma":[0.9982775,0.0009709222,0.00003102034,0.0002452433,0.0001382739,0.0001754106,0.000008425575,0.00003489631,0.0001183235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3278525,"threshold_uncertainty_score":0.5216874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2267127426001978,"score_gpt":0.5082349306894123,"score_spread":0.2815221880892145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}