{"id":"W3043818679","doi":"10.1084/jem.20200359","title":"FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex–driven autoimmunity","year":2020,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Helse Sør-Øst RHF; Harvard Digestive Diseases Center, Harvard University; Canadian Institutes of Health Research; North American Society for Pediatric Gastroenterology, Hepatology and Nutrition; NASPGHAN Foundation; Norges Forskningsråd; Universitetet i Oslo; Canadian Blood Services; Crohn's and Colitis Foundation; Deutsche Forschungsgemeinschaft; National Institutes of Health; Yale University","keywords":"Autoimmunity; Immune system; Immunology; Autoantibody; Fc receptor; Immunoglobulin G; Antibody; Inflammation; Innate immune system; Chemistry; Neonatal Fc receptor; Receptor; Immune complex; Acquired immune system; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752193,0.0002911163,0.0001687641,0.0002657046,0.0001168598,0.0002369599,0.0001304004,0.000367633,0.001794107],"category_scores_gemma":[0.0002622031,0.0001095834,0.0001239247,0.0001521341,0.0002566377,0.0001029673,0.0001933536,0.000281239,0.0002756818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002394151,"about_ca_system_score_gemma":0.0001034295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005984742,"about_ca_topic_score_gemma":0.000384224,"domain_scores_codex":[0.9998589,0.00003158153,0.00001176291,0.00003840363,0.0000237461,0.00003558553],"domain_scores_gemma":[0.9999006,0.00002363002,0.00003495426,0.000009697492,0.000007535672,0.00002363768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002091182,0.00001699467,0.005948059,0.00002129376,0.00000837807,0.0001649084,0.00002717966,0.00004124975,0.991063,0.0001126285,0.00005598592,0.002331157],"study_design_scores_gemma":[0.00007241594,0.001109051,0.2801283,0.00004164419,0.00008866192,0.008642053,0.0001848804,0.001860878,0.7000291,0.0006082873,0.007210288,0.00002443589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973565,0.001042807,0.000622538,0.00004300775,0.000006060772,0.000009378535,0.00007871955,0.00002228308,0.0008187225],"genre_scores_gemma":[0.9988505,0.0002734894,0.000305819,0.00002325201,0.000007063525,0.000004363206,0.00007349547,0.000004864088,0.0004571677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001794107,"threshold_uncertainty_score":0.00600189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.154507753894264,"score_gpt":0.3897841943523085,"score_spread":0.2352764404580445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}