{"id":"W3043857578","doi":"10.1111/acer.14416","title":"Interaction of Ethanol and Oral ANS‐6637, a Selective ALDH2 Inhibitor in Males: A Randomized, Double‐Blind, Placebo‐Controlled, Single‐Ascending Dose Cohort Study","year":2020,"lang":"en","type":"article","venue":"Alcoholism Clinical and Experimental Research","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Placebo; Medicine; Tolerability; ALDH2; Adverse effect; Pharmacokinetics; Acetaldehyde; Anesthesia; Pharmacodynamics; Randomized controlled trial; Cohort; Internal medicine; Pharmacology; Aldehyde dehydrogenase; Ethanol; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005798132,0.0002629819,0.001746223,0.0003614244,0.0001604756,0.00006285031,0.0001013483,0.0002452386,0.0001330352],"category_scores_gemma":[0.002001198,0.0002061881,0.0001987406,0.0004587984,0.0008461367,0.0002097184,0.0002674534,0.001307407,0.00002674322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001097104,"about_ca_system_score_gemma":0.0001870213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004847185,"about_ca_topic_score_gemma":0.00003897442,"domain_scores_codex":[0.9947547,0.001849142,0.001307612,0.0007843717,0.0007827024,0.0005214256],"domain_scores_gemma":[0.9957414,0.003004378,0.0001940535,0.0002002028,0.0002068074,0.0006532156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8115714,0.002398761,0.1673133,0.0001624716,0.000358601,0.00009840862,0.00617133,6.653414e-7,0.01043363,0.00006685728,0.0002761759,0.001148361],"study_design_scores_gemma":[0.947503,0.005871675,0.02520725,0.0003715865,0.0001767562,0.00004209366,0.007408908,0.00176959,0.01118638,0.00002320935,0.000175933,0.000263584],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864126,0.002301955,0.000006388941,0.001859397,0.0001719739,0.008163585,0.000002539493,0.00003557396,0.001045967],"genre_scores_gemma":[0.9971609,0.0006336531,0.0001063988,0.0008695433,0.0002694658,0.000807224,0.000009122188,0.00003143723,0.0001123033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1421061,"threshold_uncertainty_score":0.8408105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3371447464076093,"score_gpt":0.539137517735767,"score_spread":0.2019927713281577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}