{"id":"W3043857578","doi":"10.1111/acer.14416","title":"Interaction of Ethanol and Oral ANS‐6637, a Selective ALDH2 Inhibitor in Males: A Randomized, Double‐Blind, Placebo‐Controlled, Single‐Ascending Dose Cohort Study","year":2020,"lang":"en","type":"article","venue":"Alcoholism Clinical and Experimental Research","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Placebo; Medicine; Tolerability; ALDH2; Adverse effect; Pharmacokinetics; Acetaldehyde; Anesthesia; Pharmacodynamics; Randomized controlled trial; Cohort; Internal medicine; Pharmacology; Aldehyde dehydrogenase; Ethanol; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001603201,0.001874377,0.002871934,0.0005093347,0.0006631144,0.0007253015,0.00072668,0.00147657,0.005320098],"category_scores_gemma":[0.001429597,0.0009288578,0.001897263,0.0003754338,0.001083233,0.0007323502,0.00049395,0.001864339,0.0007464525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005735056,"about_ca_system_score_gemma":0.001451573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001329309,"about_ca_topic_score_gemma":0.002162764,"domain_scores_codex":[0.9991924,0.000367043,0.00006708605,0.0001495191,0.00008591441,0.0001381427],"domain_scores_gemma":[0.9987869,0.0001908984,0.0003137379,0.0001385498,0.0001194926,0.000450439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9682338,0.0165,0.002070335,0.0002353035,0.0008195969,0.00003907863,0.0000478122,0.0001145004,0.003987211,0.00002689949,0.0003042346,0.007621255],"study_design_scores_gemma":[0.6761842,0.3086403,0.0113534,0.00003019823,0.001440673,0.00005007627,0.000051496,0.0003579478,0.001259629,0.00005397409,0.0005487399,0.00002924204],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960543,0.001011698,0.0002998792,0.0001697972,0.0001646063,0.001495931,0.0004124694,0.00003907529,0.0003522518],"genre_scores_gemma":[0.9925109,0.001427983,0.000885189,0.0004805567,0.0003842452,0.002120179,0.0004713985,0.00001255129,0.001706921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005320098,"threshold_uncertainty_score":0.01779753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3371447464076093,"score_gpt":0.539137517735767,"score_spread":0.2019927713281577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}