{"id":"W3043874611","doi":"10.1371/journal.pone.0236193","title":"A genetic model of ivabradine recapitulates results from randomized clinical trials","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Heart rate and cardiovascular health","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Medical Research Council","keywords":"Ivabradine; Medicine; Atrial fibrillation; Heart failure; Internal medicine; Cardiology; Myocardial infarction; Mendelian randomization; Hazard ratio; Genome-wide association study; Clinical endpoint; Heart rate; Clinical trial; Confidence interval; Genetic variants; Single-nucleotide polymorphism; Blood pressure; Genetics; Genotype; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09274092,0.002307882,0.004623659,0.002444908,0.000704554,0.0032885,0.003696811,0.003854012,0.01213117],"category_scores_gemma":[0.1368751,0.001395896,0.007011098,0.001794164,0.003466046,0.002747051,0.001442481,0.002627125,0.00241737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002426885,"about_ca_system_score_gemma":0.004508571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0104391,"about_ca_topic_score_gemma":0.006309468,"domain_scores_codex":[0.9122391,0.0703915,0.002297051,0.009654296,0.003545826,0.001872208],"domain_scores_gemma":[0.8686131,0.106944,0.01006839,0.01049985,0.00288538,0.000989329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.02077197,0.001334575,0.1228936,0.004094584,0.03284549,0.003325559,0.001635012,0.3674644,0.007321567,0.3140024,0.02067685,0.1036341],"study_design_scores_gemma":[0.01249286,0.005504943,0.04075929,0.0007426229,0.01105088,0.00217467,0.0002402405,0.6139309,0.001137824,0.2977041,0.01395367,0.0003079738],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.243268,0.005918064,0.6929795,0.01646873,0.001321647,0.006478408,0.00826741,0.002890606,0.02240765],"genre_scores_gemma":[0.8766944,0.001558418,0.09685318,0.006162611,0.0003391932,0.006925956,0.002300842,0.0003350785,0.008830245],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.09274092,"threshold_uncertainty_score":0.4904667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3487264090204806,"score_gpt":0.3824231054274476,"score_spread":0.03369669640696693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}