{"id":"W3043901097","doi":"10.1161/circulationaha.120.045723","title":"An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of <i>CASQ2</i> -Catecholaminergic Polymorphic Ventricular Tachycardia","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Toronto General Hospital; Hospital for Sick Children; McMaster University; Université Laval; Population Health Research Institute; Montreal Heart Institute; Memorial University of Newfoundland; St. Michael's Hospital; Western University","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Catecholaminergic polymorphic ventricular tachycardia; Medicine; Cardiology; Internal medicine; Ventricular tachycardia; Tachycardia; Inheritance (genetic algorithm); Ryanodine receptor 2; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002756376,0.0001053584,0.00024924,0.00007731275,0.00003083146,0.00000684386,0.00004331831,0.00009229782,0.00003156497],"category_scores_gemma":[0.00009552226,0.0001073363,0.00008996687,0.0001396133,0.00003419713,0.0001803288,0.00001700917,0.0001177932,0.000002273531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005121823,"about_ca_system_score_gemma":0.00004433652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001772245,"about_ca_topic_score_gemma":7.210487e-7,"domain_scores_codex":[0.998874,0.0001276886,0.00028343,0.0002483444,0.000360339,0.0001061929],"domain_scores_gemma":[0.9993007,0.00002322952,0.0002021277,0.000169611,0.0002388337,0.00006556695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002459908,0.00007680515,0.09403783,0.0001391524,0.0001979707,0.00006460858,0.000348124,0.00730297,0.8852317,0.0006212868,0.000002989119,0.01173052],"study_design_scores_gemma":[0.002240758,0.0001482758,0.8450622,0.0001039587,0.0003628091,0.0001402562,0.0001163227,0.1098285,0.04112413,0.0007426219,0.000005511744,0.0001246681],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861426,0.0004410894,0.01254138,0.0002511153,0.0001303964,0.0004022565,0.00001601512,0.00002333451,0.00005180505],"genre_scores_gemma":[0.9991838,0.00005724913,0.0002854185,0.0001577872,0.0001340367,0.00001697137,0.0001493084,0.00001474001,6.409989e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8441076,"threshold_uncertainty_score":0.4377046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05920148309874312,"score_gpt":0.3184361110401893,"score_spread":0.2592346279414462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}