{"id":"W3043912809","doi":"10.1371/journal.pone.0235990","title":"Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; University of British Columbia","funders":"","keywords":"CYP2E1; Steatohepatitis; Ursodeoxycholic acid; Pharmacology; Fatty liver; Drug; Drug discovery; Alcoholic liver disease; Chemistry; Medicine; Drug design; Cytochrome P450; Biochemistry; Cirrhosis; Internal medicine; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001001523,0.0001017509,0.0003181817,0.00002647045,0.00009536534,0.000007120854,0.00005101067,0.00003681361,0.000220316],"category_scores_gemma":[0.0001322318,0.00006863697,0.00009265278,0.0000876903,0.00003937423,0.00002661212,0.00001041804,0.00006935735,0.00006913224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000506126,"about_ca_system_score_gemma":0.00006311869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001714354,"about_ca_topic_score_gemma":0.00001383946,"domain_scores_codex":[0.9991828,0.00003366078,0.0002246223,0.0001593778,0.000210147,0.00018938],"domain_scores_gemma":[0.9991803,0.0003125566,0.00009422639,0.0001647381,0.0000893761,0.0001588347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002968398,0.008539535,0.8357094,0.007916829,0.003493805,0.00006022061,0.03762442,0.00001533675,0.06840152,0.001532509,0.01185168,0.02188637],"study_design_scores_gemma":[0.03227415,0.01953132,0.4044901,0.001604178,0.0053698,0.000005006099,0.001505704,0.03125347,0.3354963,0.000067483,0.167459,0.0009434959],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835593,0.001620547,0.0001068385,0.0125214,0.00003132951,0.001722479,0.00004248547,0.00006207963,0.0003335597],"genre_scores_gemma":[0.9933971,0.001422428,0.001296672,0.002205407,0.0002866237,0.0002092508,0.00002500816,0.00002377757,0.001133757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4312193,"threshold_uncertainty_score":0.2798935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2074316281561244,"score_gpt":0.3490163274462793,"score_spread":0.1415846992901549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}