{"id":"W3043986558","doi":"10.1155/2020/9867595","title":"Nrf2 Inhibitor, Brusatol in Combination with Trastuzumab Exerts Synergistic Antitumor Activity in HER2-Positive Cancers by Inhibiting Nrf2/HO-1 and HER2-AKT/ERK1/2 Pathways","year":2020,"lang":"en","type":"article","venue":"Oxidative Medicine and Cellular Longevity","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Xinxiang Medical University; National Natural Science Foundation of China","keywords":"Trastuzumab; Protein kinase B; Pharmacology; Signal transduction; Apoptosis; Chemistry; Cancer research; Cancer; Medicine; Breast cancer; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000973059,0.0002999327,0.0003097727,0.0002569057,0.000111226,0.0001442974,0.0001450742,0.0001941915,0.0009102173],"category_scores_gemma":[0.00006833901,0.00008447776,0.0002605884,0.0001747773,0.0001061015,0.000224395,0.0001563288,0.0003513339,0.0001517847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001492802,"about_ca_system_score_gemma":0.0001624245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003318169,"about_ca_topic_score_gemma":0.001179619,"domain_scores_codex":[0.9999353,0.00001184314,0.000008280773,0.00001406513,0.00001442128,0.00001619584],"domain_scores_gemma":[0.9999768,0.00000291864,0.000007157767,0.000002810686,0.000004100318,0.000006281787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001133726,0.000301992,0.0004216023,0.0001975918,0.00004442647,0.0001274373,0.00002263836,0.0004477216,0.98245,0.0001161561,0.0002872058,0.01444966],"study_design_scores_gemma":[0.0002053518,0.002353827,0.003282923,0.00001201669,0.00009753137,0.000426501,0.00002643153,0.001533559,0.9835898,0.00007941096,0.008380448,0.00001214086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874442,0.007808973,0.00206952,0.0002252449,0.00006822664,0.00005720864,0.0002669025,0.00008310941,0.00197647],"genre_scores_gemma":[0.9928657,0.003032979,0.001543387,0.0001016508,0.0000271806,0.00004008411,0.0003415699,0.000008508508,0.002038805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009102173,"threshold_uncertainty_score":0.003045022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257901349532294,"score_gpt":0.2235968782854471,"score_spread":0.2110178647901242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}