{"id":"W3043986558","doi":"10.1155/2020/9867595","title":"Nrf2 Inhibitor, Brusatol in Combination with Trastuzumab Exerts Synergistic Antitumor Activity in HER2-Positive Cancers by Inhibiting Nrf2/HO-1 and HER2-AKT/ERK1/2 Pathways","year":2020,"lang":"en","type":"article","venue":"Oxidative Medicine and Cellular Longevity","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Xinxiang Medical University; National Natural Science Foundation of China","keywords":"Trastuzumab; Protein kinase B; Pharmacology; Signal transduction; Apoptosis; Chemistry; Cancer research; Cancer; Medicine; Breast cancer; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003031169,0.0003809993,0.000555539,0.00007703694,0.00009997782,0.00002589475,0.0001182324,0.0001635799,0.00001348794],"category_scores_gemma":[0.000219889,0.0003399884,0.00003702038,0.0002404077,0.0005327532,0.0000317727,0.0001287949,0.000351808,0.000001043529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000103315,"about_ca_system_score_gemma":0.0001093563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006921528,"about_ca_topic_score_gemma":0.0006476406,"domain_scores_codex":[0.9979767,0.0002364773,0.0003435647,0.000833296,0.0002313507,0.0003786454],"domain_scores_gemma":[0.9992179,0.00006561899,0.0002158982,0.0001681448,0.0001012667,0.0002311158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004025779,0.000157648,0.01686655,0.0001593487,0.00004171546,0.00006661035,0.001508113,0.000007997465,0.9774003,0.00003874579,0.0002876251,0.003062768],"study_design_scores_gemma":[0.003361039,0.001245277,0.01009873,0.000354889,0.00004406647,0.000007320019,0.001631839,0.0002208508,0.9822131,0.00006514839,0.0003204781,0.0004372948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939797,0.001967496,0.002108654,0.0008041291,0.00004356517,0.0005537705,0.00009028998,0.00001219039,0.000440242],"genre_scores_gemma":[0.9985537,0.0004394667,0.000103931,0.0003259101,0.0001474301,0.00004125303,0.000327239,0.00003303599,0.00002802314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006767813,"threshold_uncertainty_score":0.9999052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257901349532294,"score_gpt":0.2235968782854471,"score_spread":0.2110178647901242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}