{"id":"W3044027236","doi":"10.1038/s41598-020-68995-z","title":"IL-10 attenuates OxPCs-mediated lipid metabolic responses in ischemia reperfusion injury","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Research Manitoba; Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Kexin; Oxidative stress; PCSK9; Inflammation; TLR2; Downregulation and upregulation; Chemistry; Sterol regulatory element-binding protein; Receptor; Reperfusion injury; Lipoprotein; Internal medicine; Endocrinology; Ischemia; LDL receptor; Cell biology; Biochemistry; TLR4; Biology; Medicine; Cholesterol; Sterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002894682,0.0007269894,0.0005999142,0.000259971,0.00009682755,0.0002977364,0.0001992036,0.0003607683,0.001718367],"category_scores_gemma":[0.000189663,0.0001655421,0.0003023917,0.0001272937,0.0003044455,0.000240639,0.0002476391,0.001422599,0.0003889728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001625703,"about_ca_system_score_gemma":0.000341047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003202705,"about_ca_topic_score_gemma":0.0003943725,"domain_scores_codex":[0.9998202,0.00003929506,0.00001791221,0.00001998953,0.00003044391,0.00007226365],"domain_scores_gemma":[0.9998329,0.00001635466,0.00004680047,0.00001432662,0.0000217409,0.00006785132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004302003,0.0009839868,0.0003807423,0.0002822484,0.00002380531,0.0001035834,0.00004249394,0.000156748,0.9857137,0.0000784283,0.0002661437,0.007665983],"study_design_scores_gemma":[0.0006665324,0.01198279,0.007932687,0.00008576522,0.0001116497,0.0003711185,0.0001288565,0.002234999,0.9723175,0.0001346165,0.004019808,0.00001382044],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900506,0.004927026,0.002451789,0.0003107307,0.0002466536,0.0000976089,0.0002375125,0.0002674998,0.00141044],"genre_scores_gemma":[0.9918512,0.002638998,0.001641266,0.00022466,0.0001122055,0.0001448665,0.0004378368,0.00002570844,0.002923305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718367,"threshold_uncertainty_score":0.00574851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0151126839391,"score_gpt":0.232181501148214,"score_spread":0.217068817209114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}