{"id":"W3044045036","doi":"10.1158/2159-8290.cd-20-0133","title":"Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University Health Network; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Uehara Memorial Foundation; Deutsche Forschungsgemeinschaft; Cold Spring Harbor Laboratory; Breast Cancer Research Foundation; National Cancer Institute; National Institutes of Health; Daiichi Sankyo Foundation of Life Science; Pershing Square Sohn Cancer Research Alliance; Simons Foundation","keywords":"Pancreatic ductal adenocarcinoma; Adenocarcinoma; Transplantation; Pancreatic carcinoma; Cancer research; Biology; Pathology; Transition (genetics); Medicine; Internal medicine; Pancreatic cancer; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005179598,0.0003586765,0.0002610141,0.0003847963,0.0002638713,0.0008065113,0.0004719479,0.0005529808,0.001342249],"category_scores_gemma":[0.0002231941,0.0002113192,0.000389254,0.0002533176,0.0006246108,0.000543927,0.0005452961,0.002256474,0.0005772559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006384386,"about_ca_system_score_gemma":0.0002792192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009962479,"about_ca_topic_score_gemma":0.001358162,"domain_scores_codex":[0.9996518,0.00007929176,0.00002826345,0.00007535238,0.0001288417,0.00003646198],"domain_scores_gemma":[0.9996541,0.00009280533,0.00008460489,0.00007800361,0.00004037488,0.00005013381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002725273,0.0001247793,0.0007658402,0.00009011931,0.00001398807,0.0002846262,0.0001170188,0.0008052348,0.9876672,0.002927624,0.0008545651,0.006076351],"study_design_scores_gemma":[0.00003604352,0.000718175,0.002539415,0.00004048302,0.00004336312,0.00107398,0.0001458578,0.005100607,0.9702487,0.0008085624,0.01922679,0.00001801972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.87133,0.01271478,0.08934411,0.002606038,0.0008229025,0.0002482872,0.001859294,0.001097266,0.0199773],"genre_scores_gemma":[0.9629864,0.004986477,0.01698285,0.0003614363,0.00005532844,0.0001013126,0.001138325,0.0001364045,0.01325146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001342249,"threshold_uncertainty_score":0.004632235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03556222082834021,"score_gpt":0.321518795484675,"score_spread":0.2859565746563348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}