{"id":"W3044045036","doi":"10.1158/2159-8290.cd-20-0133","title":"Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University Health Network; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Uehara Memorial Foundation; Deutsche Forschungsgemeinschaft; Cold Spring Harbor Laboratory; Breast Cancer Research Foundation; National Cancer Institute; National Institutes of Health; Daiichi Sankyo Foundation of Life Science; Pershing Square Sohn Cancer Research Alliance; Simons Foundation","keywords":"Pancreatic ductal adenocarcinoma; Adenocarcinoma; Transplantation; Pancreatic carcinoma; Cancer research; Biology; Pathology; Transition (genetics); Medicine; Internal medicine; Pancreatic cancer; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007537543,0.0001253267,0.0005255156,0.00006211912,0.00003023862,0.000005747339,0.00007731909,0.00008564069,0.00007554397],"category_scores_gemma":[0.00001698814,0.0001094583,0.0001159445,0.0001748202,0.0002448832,0.0002128262,0.000009471776,0.0001456195,0.000001167661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005265737,"about_ca_system_score_gemma":0.0003213731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001066459,"about_ca_topic_score_gemma":0.000004288735,"domain_scores_codex":[0.9988623,0.00006769243,0.0003494843,0.000231026,0.0003081404,0.000181385],"domain_scores_gemma":[0.9994817,0.0000337513,0.0001293302,0.0001333127,0.0001135047,0.000108384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003752866,0.0003346842,0.2474911,0.004380336,0.0007418874,0.0005278194,0.009736718,0.000265286,0.7288424,0.003316999,0.0001866363,0.0004231672],"study_design_scores_gemma":[0.008921863,0.005334597,0.4813685,0.002039153,0.004045722,0.0002421771,0.002113144,0.006017791,0.4859923,0.003435496,0.000004084141,0.0004852637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920177,0.002931655,0.002531883,0.001265559,0.00002672137,0.0005334467,0.0001218989,0.00001511308,0.0005560528],"genre_scores_gemma":[0.99874,0.000414563,0.0003310452,0.0001625355,0.000115166,0.00006283404,0.0001174229,0.00001839905,0.00003806922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2428502,"threshold_uncertainty_score":0.4463578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03556222082834021,"score_gpt":0.321518795484675,"score_spread":0.2859565746563348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}