{"id":"W3044059177","doi":"10.3389/fphar.2021.633680","title":"COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms","year":2021,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; U.S. Air Force; Defense Advanced Research Projects Agency; Defense Threat Reduction Agency; Advanced Research Projects Agency; National Institutes of Health; Office of Extramural Research, National Institutes of Health; U.S. Department of Defense","keywords":"Famotidine; Medicine; Histamine; Disease; Repurposing; Drug repositioning; Coronavirus disease 2019 (COVID-19); Drug; Pandemic; Histamine receptor; Mechanism of action; Immunology; Pharmacology; Infectious disease (medical specialty); Internal medicine; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002212455,0.0001710087,0.0002272964,0.00008433534,0.0000810135,0.00001651248,0.0001401771,0.000198029,0.0007198047],"category_scores_gemma":[0.00006262265,0.0001880394,0.00005735824,0.0001248923,0.00007178765,0.000004359399,0.0001474861,0.0001416681,0.000003244049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000599113,"about_ca_system_score_gemma":0.0002585407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001147505,"about_ca_topic_score_gemma":0.00001300971,"domain_scores_codex":[0.9987273,0.0001528249,0.0002170933,0.0004892367,0.00008537411,0.000328187],"domain_scores_gemma":[0.9994486,0.00001290225,0.00006204318,0.0001483803,0.00004342313,0.0002846602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006807541,0.00005745049,0.0003484552,0.00003264539,0.00004836582,0.0001032788,0.00004443902,0.0001542673,0.9181516,0.000410405,0.07962912,0.000951915],"study_design_scores_gemma":[0.001208483,0.0001024871,0.00002748799,0.000002730628,0.00002641578,0.00003984254,0.000298969,0.000561211,0.8051571,0.001536926,0.1908424,0.0001959193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2514839,0.007165245,0.7305941,0.001541304,0.007549089,0.0004098419,0.00007878539,0.00004186123,0.00113588],"genre_scores_gemma":[0.9077815,0.003570082,0.07205687,0.01095577,0.0005307748,0.0000860982,0.00025645,0.00006926745,0.004693156],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6585372,"threshold_uncertainty_score":0.7881356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008903672197287632,"score_gpt":0.2560673604310783,"score_spread":0.2471636882337907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}