{"id":"W3044059177","doi":"10.3389/fphar.2021.633680","title":"COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms","year":2021,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; U.S. Air Force; Defense Advanced Research Projects Agency; Defense Threat Reduction Agency; Advanced Research Projects Agency; National Institutes of Health; Office of Extramural Research, National Institutes of Health; U.S. Department of Defense","keywords":"Famotidine; Medicine; Histamine; Disease; Repurposing; Drug repositioning; Coronavirus disease 2019 (COVID-19); Drug; Pandemic; Histamine receptor; Mechanism of action; Immunology; Pharmacology; Infectious disease (medical specialty); Internal medicine; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006858298,0.0005976298,0.0005490507,0.000490907,0.0003444153,0.001032409,0.0004526918,0.001296598,0.002461309],"category_scores_gemma":[0.0002308742,0.0001777204,0.0004138302,0.0003216579,0.0008146701,0.001129681,0.000522409,0.001167145,0.0005605142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008306697,"about_ca_system_score_gemma":0.0005054281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007523294,"about_ca_topic_score_gemma":0.0007465606,"domain_scores_codex":[0.9997972,0.00005392379,0.00001438247,0.00003989339,0.00004006596,0.00005455812],"domain_scores_gemma":[0.9998193,0.00003160228,0.00006533703,0.000008407716,0.00002589072,0.00004954025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.005030705,0.0007538472,0.007626319,0.006303705,0.0002306754,0.005494816,0.0003870184,0.001124999,0.6257699,0.01739631,0.01118077,0.318701],"study_design_scores_gemma":[0.0008977322,0.01378715,0.1428128,0.002061778,0.0006168848,0.02629349,0.001791386,0.00585578,0.3681664,0.03122192,0.4062433,0.0002513294],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1265004,0.8384091,0.007805167,0.01408484,0.001149581,0.000151219,0.0004449638,0.0002349923,0.0112196],"genre_scores_gemma":[0.6638621,0.3151622,0.004199912,0.0051435,0.001641283,0.00012989,0.0004656502,0.00001904808,0.009376408],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002461309,"threshold_uncertainty_score":0.008233905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008903672197287632,"score_gpt":0.2560673604310783,"score_spread":0.2471636882337907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}