{"id":"W3044111226","doi":"10.1158/2326-6066.cir-20-0196","title":"The Gut Microbiome Associates with Immune Checkpoint Inhibition Outcomes in Patients with Advanced Non–Small Cell Lung Cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":300,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal","funders":"Cancéropôle Ile de France; Institut National Du Cancer; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Labex Immuno-Oncology; Seerave Foundation; Japan Society for the Promotion of Science London; Association pour la Recherche sur le Cancer","keywords":"Microbiome; Gut microbiome; Lung cancer; Immune system; Immune checkpoint; Medicine; Immunology; Immunotherapy; Pembrolizumab; Cancer; Cancer immunotherapy; Cancer research; Biology; Oncology; Bioinformatics; Gut flora; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002096721,0.0001773757,0.0003169695,0.0003661442,0.0003974281,0.0004167155,0.0001111533,0.0003013573,0.001014267],"category_scores_gemma":[0.0008033614,0.0001317753,0.0002659218,0.0005450044,0.0001527312,0.0002964937,0.0003973042,0.0003823668,0.0001209836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000209522,"about_ca_system_score_gemma":0.0001610579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002048987,"about_ca_topic_score_gemma":0.003048919,"domain_scores_codex":[0.9998347,0.00004131813,0.00002116019,0.00004148277,0.00002014912,0.00004112954],"domain_scores_gemma":[0.9995472,0.00005234473,0.0002154881,0.0000220531,0.00006073287,0.0001022102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002078654,0.00002669699,0.9971446,0.00001223623,0.0000404061,0.00004428229,0.00002782282,0.00003078564,0.0008713937,0.000005998549,0.00009160527,0.001496268],"study_design_scores_gemma":[0.000004357917,0.0001008832,0.9991879,0.000004791602,0.00002535516,0.0001061648,0.0000920766,0.0002158733,0.00008777461,0.00001788509,0.0001548584,0.000002126333],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988536,0.000571423,0.00006079373,0.00005049604,0.000006878496,0.000005097483,0.0002259595,0.000002100714,0.0002236804],"genre_scores_gemma":[0.9996287,0.00007530853,0.00004389023,0.00002118425,0.000006655961,0.000004085072,0.0001510314,7.879933e-7,0.00006824068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002048987,"threshold_uncertainty_score":0.004074097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142274996646788,"score_gpt":0.3081915938968357,"score_spread":0.2939640942321569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}