{"id":"W3044111226","doi":"10.1158/2326-6066.cir-20-0196","title":"The Gut Microbiome Associates with Immune Checkpoint Inhibition Outcomes in Patients with Advanced Non–Small Cell Lung Cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":300,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal","funders":"Cancéropôle Ile de France; Institut National Du Cancer; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Labex Immuno-Oncology; Seerave Foundation; Japan Society for the Promotion of Science London; Association pour la Recherche sur le Cancer","keywords":"Microbiome; Gut microbiome; Lung cancer; Immune system; Immune checkpoint; Medicine; Immunology; Immunotherapy; Pembrolizumab; Cancer; Cancer immunotherapy; Cancer research; Biology; Oncology; Bioinformatics; Gut flora; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003359263,0.0002138057,0.0002918823,0.00007579004,0.0003273403,0.00004034094,0.0003341863,0.0002088912,0.00002839429],"category_scores_gemma":[0.00004271289,0.0001402732,0.00005380246,0.0003699213,0.0003502784,0.000009459472,0.0002447608,0.0006087475,0.000009838202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002264444,"about_ca_system_score_gemma":0.0006395835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005500252,"about_ca_topic_score_gemma":0.001172004,"domain_scores_codex":[0.9980416,0.0001982658,0.0003007105,0.0004997538,0.0001613241,0.0007983458],"domain_scores_gemma":[0.9989824,0.00004286089,0.0001383763,0.0003441317,0.000412506,0.00007972976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00106506,0.00009249939,0.2969707,0.00005736325,0.0001227218,0.000002792365,0.0003108609,0.00002661718,0.7004116,0.000002395281,0.0003196026,0.0006178644],"study_design_scores_gemma":[0.005151574,0.001313337,0.7371442,0.000106828,0.00001794172,9.659653e-7,0.0003783436,0.000008778371,0.2518724,0.000003275987,0.003729915,0.0002723659],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869152,0.008266091,0.00001164498,0.003638282,0.00009237792,0.0008845289,0.00007181468,0.00001093768,0.0001091661],"genre_scores_gemma":[0.9958062,0.002618427,0.00007955258,0.0003191342,0.00005267561,0.0003579441,0.0001306675,0.00004334692,0.0005920212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4485391,"threshold_uncertainty_score":0.5720176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142274996646788,"score_gpt":0.3081915938968357,"score_spread":0.2939640942321569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}