{"id":"W3044281570","doi":"10.1158/1538-7445.pedca19-ia02","title":"Abstract IA02: Novel strategies for early cancer detection and prevention: The Li-Fraumeni syndrome story","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"","keywords":"Li–Fraumeni syndrome; Germline; Cancer; Germline mutation; Epigenome; Medicine; Mutation; Genetics; Cancer research; Biology; Internal medicine; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00753831,0.001312249,0.001321364,0.001770102,0.001254273,0.004178074,0.00183511,0.008800367,0.01119296],"category_scores_gemma":[0.01625722,0.0004031805,0.001322094,0.0008297683,0.003914651,0.005831805,0.002362429,0.01747069,0.007325875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002991954,"about_ca_system_score_gemma":0.002336055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003500079,"about_ca_topic_score_gemma":0.002758706,"domain_scores_codex":[0.9981123,0.0007276078,0.000143739,0.0003400875,0.000475104,0.0002011184],"domain_scores_gemma":[0.9913952,0.003857219,0.0004385066,0.0005105608,0.002473949,0.001324598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003132065,0.00009914579,0.001138749,0.0007496034,0.0001103373,0.000514322,0.0001888748,0.0004440108,0.001348718,0.02748591,0.7116511,0.2559559],"study_design_scores_gemma":[0.0001376496,0.000194168,0.001610145,0.001252022,0.00009956886,0.001061254,0.0002974667,0.0006041008,0.001296884,0.04663973,0.9467273,0.00007965501],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.001847895,0.2096959,0.003895159,0.7291502,0.04301617,0.00002727354,0.0004767633,0.000413788,0.01147689],"genre_scores_gemma":[0.04850732,0.3907297,0.00883458,0.3896762,0.1088512,0.0001356616,0.0008068362,0.0004311671,0.05202718],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01119296,"threshold_uncertainty_score":0.03986686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1352196211745304,"score_gpt":0.4074796587114322,"score_spread":0.2722600375369018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}