{"id":"W3044362284","doi":"10.1101/2020.07.21.20159129","title":"Plasma amyloid, phosphorylated tau, and neurofilament light for individualized risk prediction in mild cognitive impairment","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Stiftelsen Bundy Academy; IXICO; H. Lundbeck A/S; Genentech; Marcus och Amalia Wallenbergs minnesfond; Knut och Alice Wallenbergs Stiftelse; Servier; Skånes universitetssjukhus; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Vetenskapsrådet; Eisai; Lunds Universitet; Northern California Institute for Research and Education; Sveriges Läkarförbund; Pfizer; Biogen; BioClinica; Australian Government; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Alzheimer's Disease Neuroimaging Initiative; Neurodegeneration; Oncology; Internal medicine; Cognition; Cerebrospinal fluid; Neuroimaging; Disease; Amyloid (mycology); Medicine; Cognitive decline; Biomarker; Psychology; Cognitive impairment; Neuroscience; Pathology; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005995491,0.001225819,0.001075542,0.001188888,0.0003761938,0.00117534,0.0007963383,0.0007129765,0.001472976],"category_scores_gemma":[0.009549882,0.0004172217,0.001323024,0.0004601591,0.0003451808,0.0004836686,0.0008146763,0.0009448837,0.0003499427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001061975,"about_ca_system_score_gemma":0.001654949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01448477,"about_ca_topic_score_gemma":0.008712278,"domain_scores_codex":[0.9987999,0.0008110084,0.00004764745,0.0001745814,0.00008226565,0.00008454985],"domain_scores_gemma":[0.9963894,0.002809817,0.0002700556,0.0001458531,0.0001990756,0.0001856726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.004290178,0.0009141833,0.2933606,0.0001355359,0.002034602,0.0004180786,0.0001774539,0.6126865,0.001069958,0.001531189,0.004945154,0.07843664],"study_design_scores_gemma":[0.0001738369,0.0003072955,0.0231502,0.0000481684,0.0001759576,0.00007575296,0.00003451675,0.9705941,0.0004282465,0.004551154,0.0004267063,0.00003404455],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9297224,0.001513107,0.06368946,0.001155718,0.0001045091,0.0001628681,0.001564827,0.0006701862,0.001416962],"genre_scores_gemma":[0.9842673,0.0001439471,0.01379423,0.0001169995,0.00004473547,0.0001087917,0.0007520454,0.00002368284,0.0007483886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01448477,"threshold_uncertainty_score":0.03170758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02803922979493626,"score_gpt":0.3084288955705397,"score_spread":0.2803896657756034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}