{"id":"W3044387220","doi":"10.1016/j.stem.2020.11.001","title":"The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization","year":2020,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; SickKids Foundation; University of Toronto; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Japan Society for the Promotion of Science; Canada First Research Excellence Fund; Canada Research Chairs; Celgene; Government of Ontario; University of Toronto; Canadian Cancer Society; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Biology; Chromatin; CTCF; Stem cell; Haematopoiesis; Cell biology; Progenitor cell; Gene silencing; Transcription factor; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005380387,0.00008631195,0.0001443248,0.0002483163,0.00024486,0.000838374,0.0001698954,0.0002168978,0.001192175],"category_scores_gemma":[0.00014664,0.0001741107,0.0002024842,0.0002523698,0.0003002085,0.0002878922,0.0002989558,0.000300372,0.0003694544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002559081,"about_ca_system_score_gemma":0.0001722723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000719711,"about_ca_topic_score_gemma":0.001401728,"domain_scores_codex":[0.9999403,0.000007204431,0.000002596706,0.00001670272,0.00001766926,0.00001558965],"domain_scores_gemma":[0.9999298,0.0000163307,0.00001773139,0.00001155742,0.000009177597,0.00001536513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001943543,0.00002501726,0.003499161,0.00004535228,0.00001701681,0.000193985,0.0002558666,0.001263981,0.9803767,0.002289676,0.0004694185,0.01136938],"study_design_scores_gemma":[0.00005354096,0.0002341371,0.2589029,0.00002956937,0.00005488916,0.001112085,0.001083146,0.01223555,0.6931267,0.004048997,0.0290417,0.00007678411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870735,0.0016575,0.006211025,0.0001419838,0.00003303401,0.00001501021,0.0004714359,0.0001198716,0.004276513],"genre_scores_gemma":[0.9973685,0.0003780096,0.0009966919,0.00005073439,0.000006161163,0.00001384325,0.0002817041,0.00002461184,0.0008798845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192175,"threshold_uncertainty_score":0.003988266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008950640535435001,"score_gpt":0.2173671183794996,"score_spread":0.2084164778440646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}