{"id":"W3044387220","doi":"10.1016/j.stem.2020.11.001","title":"The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization","year":2020,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; SickKids Foundation; University of Toronto; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Japan Society for the Promotion of Science; Canada First Research Excellence Fund; Canada Research Chairs; Celgene; Government of Ontario; University of Toronto; Canadian Cancer Society; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation","keywords":"Biology; Chromatin; CTCF; Stem cell; Haematopoiesis; Cell biology; Progenitor cell; Gene silencing; Transcription factor; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001797104,0.0003828513,0.0005067576,0.00007296489,0.0001881515,0.00008911368,0.0002553817,0.0002014012,0.0002791114],"category_scores_gemma":[0.000001770386,0.0003340903,0.00009564522,0.0005837493,0.0000498644,0.0001087165,0.00003489312,0.0003119047,0.0004284113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003776346,"about_ca_system_score_gemma":0.00007550992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001069459,"about_ca_topic_score_gemma":0.00002540834,"domain_scores_codex":[0.9972567,0.0001747031,0.0007946924,0.0006990726,0.0005805395,0.000494292],"domain_scores_gemma":[0.9987091,0.0001803054,0.0002053464,0.0004427747,0.00009382411,0.0003686901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002490978,0.0002212249,0.0001818817,0.0006684851,0.00002837387,0.00004364245,0.02292837,0.0002092497,0.9742599,0.000003082461,0.0009852118,0.0002215093],"study_design_scores_gemma":[0.002392757,0.0003172113,0.0003975472,0.0001877401,0.0001360422,0.000004428844,0.005891775,0.001655915,0.9856522,0.00001395651,0.002987128,0.0003632801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988691,0.0005281354,0.005301547,0.00256549,0.0001382645,0.00162624,0.0002497861,0.000153402,0.0007461681],"genre_scores_gemma":[0.9960221,0.0003625452,0.0001567466,0.001489286,0.00004808546,0.00003946193,0.000544432,0.0001129317,0.001224414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01703659,"threshold_uncertainty_score":0.9999111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008950640535435001,"score_gpt":0.2173671183794996,"score_spread":0.2084164778440646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}