{"id":"W3044462916","doi":"10.1186/s13023-020-01435-3","title":"Wound closure in epidermolysis bullosa: data from the vehicle arm of the phase 3 ESSENCE Study","year":2020,"lang":"en","type":"article","venue":"Orphanet Journal of Rare Diseases","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Galderma; Mylan; Amicus Therapeutics; Regeneron Pharmaceuticals; Celgene; Sanofi; Valeant Pharmaceuticals International; Pfizer","keywords":"Epidermolysis bullosa; Phase (matter); Medicine; Closure (psychology); Wound healing; Junctional epidermolysis bullosa (veterinary medicine); Wound closure; Dermatology; Surgery; Biology; Chemistry; Genetics; Political science; Mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003028227,0.0005539458,0.001477954,0.0002116225,0.0001690657,0.0007644354,0.000484567,0.0006381305,0.002910371],"category_scores_gemma":[0.002426802,0.0001883065,0.001631272,0.0002995087,0.0003817973,0.0006611273,0.0003333652,0.0009692241,0.0003248831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002313829,"about_ca_system_score_gemma":0.0005596376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00036525,"about_ca_topic_score_gemma":0.0007299302,"domain_scores_codex":[0.9989192,0.00066703,0.00008810975,0.00009245251,0.0001303214,0.0001028906],"domain_scores_gemma":[0.9977894,0.0007413657,0.0007714226,0.0002203733,0.0002097075,0.0002678159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8709809,0.009195168,0.02090579,0.003520254,0.008642987,0.0001426849,0.0001621509,0.001010911,0.01165005,0.0003376381,0.004025944,0.06942546],"study_design_scores_gemma":[0.6245536,0.2683189,0.0885746,0.0003870328,0.0070566,0.0004911814,0.0002023517,0.001003927,0.002517459,0.0004270946,0.006407531,0.00005968358],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828486,0.01109142,0.0007605123,0.0003062587,0.00008910444,0.0008323487,0.002618734,0.00004773357,0.001405122],"genre_scores_gemma":[0.9894863,0.00449159,0.000608535,0.0006058422,0.0001225797,0.0007859075,0.003219697,0.00001945395,0.0006601146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003028227,"threshold_uncertainty_score":0.01601499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03618213935787074,"score_gpt":0.3162666230776912,"score_spread":0.2800844837198204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}