{"id":"W3044462916","doi":"10.1186/s13023-020-01435-3","title":"Wound closure in epidermolysis bullosa: data from the vehicle arm of the phase 3 ESSENCE Study","year":2020,"lang":"en","type":"article","venue":"Orphanet Journal of Rare Diseases","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Galderma; Mylan; Amicus Therapeutics; Regeneron Pharmaceuticals; Celgene; Sanofi; Valeant Pharmaceuticals International; Pfizer","keywords":"Epidermolysis bullosa; Phase (matter); Medicine; Closure (psychology); Wound healing; Junctional epidermolysis bullosa (veterinary medicine); Wound closure; Dermatology; Surgery; Biology; Chemistry; Genetics; Political science; Mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002964027,0.0001117895,0.0002162728,0.00001763529,0.00006891924,0.00002187443,0.001314508,0.00005894707,0.0001371388],"category_scores_gemma":[0.000818932,0.00006229946,0.0001177023,0.00018705,0.0001628844,0.000008762751,0.00043051,0.0001902277,0.000003202633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005353923,"about_ca_system_score_gemma":0.0002073246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004187956,"about_ca_topic_score_gemma":0.00003612156,"domain_scores_codex":[0.9985571,0.0004498324,0.0003363799,0.0002330805,0.0002681049,0.0001554838],"domain_scores_gemma":[0.9988248,0.0001262722,0.0002299044,0.0006064436,0.0001048967,0.0001077108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001972221,0.002333544,0.6610699,0.00002768451,0.0006302462,0.00113166,0.000391325,0.00006593289,0.3169822,0.000006594359,0.01285692,0.002531749],"study_design_scores_gemma":[0.02613111,0.009444186,0.5970191,0.0003944815,0.002034325,0.001039657,0.02164298,0.001092072,0.3133834,0.0007941768,0.0257802,0.00124423],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893785,0.008332488,0.00003272953,0.001577247,0.00007664049,0.000183611,0.0004028868,0.000001369121,0.00001452501],"genre_scores_gemma":[0.9989891,0.000293183,0.00001340672,0.0002304479,0.0003093338,0.000002649503,0.0001337669,0.000009660306,0.0000184693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06405076,"threshold_uncertainty_score":0.2540498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03618213935787074,"score_gpt":0.3162666230776912,"score_spread":0.2800844837198204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}