{"id":"W3044480534","doi":"10.15252/embr.201949886","title":"Key phosphorylation sites in GPCRs orchestrate the contribution of β‐Arrestin 1 in ERK1/2 activation","year":2020,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Instituto de Salud Carlos III; Science and Engineering Research Board; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology; Wellcome Trust; Council of Scientific and Industrial Research, India; Fonds de Recherche du Québec - Santé; Department of Science and Technology, Ministry of Science and Technology, India; Department of Biotechnology, Ministry of Science and Technology, India; Indian Institute of Technology Kanpur; The Wellcome Trust DBT India Alliance; Government of Canada; Narodowe Centrum Nauki; Japan Agency for Medical Research and Development","keywords":"Phosphorylation; G protein-coupled receptor; Arrestin; MAPK/ERK pathway; Key (lock); Cell biology; Chemistry; Biology; Signal transduction; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799226,0.000295734,0.000217495,0.0002657459,0.0003173511,0.0004056853,0.0002334352,0.0002604662,0.003440382],"category_scores_gemma":[0.0002145534,0.0002046265,0.0002543452,0.0001632974,0.0003079456,0.0003858656,0.0002827737,0.0005739319,0.0009245931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004072354,"about_ca_system_score_gemma":0.0002330372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004836123,"about_ca_topic_score_gemma":0.001578768,"domain_scores_codex":[0.9998741,0.00001758216,0.000006913138,0.00002394291,0.00002396248,0.00005343586],"domain_scores_gemma":[0.9999026,0.00001606448,0.00002977036,0.000006110202,0.000008823101,0.00003663256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005678598,0.00003454529,0.0006456914,0.00005349545,0.00001113966,0.0001426245,0.00003591025,0.0003377218,0.9942316,0.001383123,0.0002371336,0.002319201],"study_design_scores_gemma":[0.0001078525,0.0002588943,0.06839478,0.00003129815,0.00004476935,0.0008297703,0.0002109625,0.004531903,0.9184472,0.001493701,0.005611383,0.0000374692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930266,0.001454032,0.002120957,0.0002858104,0.00004728137,0.00002109876,0.0003429758,0.00005881097,0.002642556],"genre_scores_gemma":[0.9959065,0.0009531672,0.001137886,0.00008079791,0.00001922416,0.00001574776,0.0003433528,0.00002669048,0.001516553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003440382,"threshold_uncertainty_score":0.01150924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631510993251569,"score_gpt":0.2406974967799777,"score_spread":0.224382386847462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}