{"id":"W3044480534","doi":"10.15252/embr.201949886","title":"Key phosphorylation sites in GPCRs orchestrate the contribution of β‐Arrestin 1 in ERK1/2 activation","year":2020,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Instituto de Salud Carlos III; Science and Engineering Research Board; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology; Wellcome Trust; Council of Scientific and Industrial Research, India; Fonds de Recherche du Québec - Santé; Department of Science and Technology, Ministry of Science and Technology, India; Department of Biotechnology, Ministry of Science and Technology, India; Indian Institute of Technology Kanpur; The Wellcome Trust DBT India Alliance; Government of Canada; Narodowe Centrum Nauki; Japan Agency for Medical Research and Development","keywords":"Phosphorylation; G protein-coupled receptor; Arrestin; MAPK/ERK pathway; Key (lock); Cell biology; Chemistry; Biology; Signal transduction; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003394093,0.00006891919,0.00009879501,0.0000192062,0.00001975454,0.000009397397,0.00004138512,0.00008334193,0.00002903003],"category_scores_gemma":[0.0003650766,0.00005621968,0.00003212794,0.0001364655,0.00001634276,0.000005535279,0.00002177037,0.00007536865,6.945069e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001291586,"about_ca_system_score_gemma":0.00005423443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006711818,"about_ca_topic_score_gemma":0.00004642664,"domain_scores_codex":[0.9992729,0.00005048193,0.0002973324,0.0001840349,0.00009548885,0.0000996918],"domain_scores_gemma":[0.9996132,0.00001385207,0.0001821119,0.0001146619,0.00005166998,0.00002454853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004406496,0.00001636857,0.02964857,0.000005248478,0.000004734139,0.000009695251,0.0001734837,0.001718174,0.9677528,0.0001154933,0.00007091123,0.0004405093],"study_design_scores_gemma":[0.0001694913,0.00007111197,0.01893695,0.00001967755,0.000003007335,0.00000492158,0.00008547858,0.0007470386,0.9786939,0.0004158604,0.0007856417,0.00006692311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973834,0.0001418784,0.00171476,0.0003139012,0.00004768423,0.0001796835,8.769308e-7,0.000004494774,0.0002133726],"genre_scores_gemma":[0.9995441,0.00001971664,0.0001421952,0.00009302977,0.00006101929,0.00001184178,0.0001062663,0.000006570728,0.00001528423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01094115,"threshold_uncertainty_score":0.2292572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631510993251569,"score_gpt":0.2406974967799777,"score_spread":0.224382386847462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}