{"id":"W3044496248","doi":"10.1038/s41467-020-17227-z","title":"Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Institutes of Health; Education Department of Henan Province; National Natural Science Foundation of China","keywords":"Epigenetics; Biology; DNA methylation; PRC2; CTCF; Epigenomics; EZH2; Wnt signaling pathway; Polycomb-group proteins; Promoter; Enhancer; Genetics; Computational biology; Phenotype; Methylation; Heterochromatin; Gene; H3K4me3; Regulation of gene expression; Cancer research; Gene expression; Chromatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096905,0.0001274225,0.0002130803,0.0002435336,0.0001265147,0.0003256475,0.00009158976,0.0001278562,0.0009895241],"category_scores_gemma":[0.0001229125,0.0001082992,0.0001375074,0.0002433987,0.0001596611,0.0001387855,0.0002957701,0.000208572,0.0002231388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001852837,"about_ca_system_score_gemma":0.0001272112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006389968,"about_ca_topic_score_gemma":0.001468836,"domain_scores_codex":[0.999922,0.000008212837,0.000004691599,0.00002263334,0.00002740233,0.00001509168],"domain_scores_gemma":[0.999954,0.000005830796,0.00001552501,0.000007008027,0.000007782773,0.000009931523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001034608,0.00001163869,0.01785831,0.00003467485,0.00002500365,0.0001505472,0.00003478545,0.0003051787,0.9759004,0.0001651765,0.0000965775,0.005314355],"study_design_scores_gemma":[0.000009782463,0.0001773345,0.662733,0.00001415847,0.0000754529,0.001286953,0.0002164112,0.004609109,0.3264738,0.0005683991,0.003820319,0.0000152945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939027,0.001559293,0.002679577,0.00007282524,0.000007913715,0.000007946554,0.0004781374,0.00008378378,0.00120788],"genre_scores_gemma":[0.9982084,0.0004438047,0.0005775825,0.00003326518,0.000003497692,0.000004768197,0.0002287276,0.000007932249,0.0004920741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009895241,"threshold_uncertainty_score":0.003310323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02237574770117329,"score_gpt":0.2813455017146993,"score_spread":0.258969754013526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}