{"id":"W3044496248","doi":"10.1038/s41467-020-17227-z","title":"Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; National Institutes of Health; Education Department of Henan Province; National Natural Science Foundation of China","keywords":"Epigenetics; Biology; DNA methylation; PRC2; CTCF; Epigenomics; EZH2; Wnt signaling pathway; Polycomb-group proteins; Promoter; Enhancer; Genetics; Computational biology; Phenotype; Methylation; Heterochromatin; Gene; H3K4me3; Regulation of gene expression; Cancer research; Gene expression; Chromatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001198725,0.0001448641,0.0001450054,0.00004165597,0.00013494,0.00001388407,0.0005890433,0.0003640075,0.00001004465],"category_scores_gemma":[0.0002063371,0.0001462646,0.00008692525,0.0001803806,0.00008646611,0.000005165024,0.0002503708,0.0002704166,0.000004805696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001029868,"about_ca_system_score_gemma":0.00006227196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007848978,"about_ca_topic_score_gemma":0.00002487402,"domain_scores_codex":[0.9989634,0.0001801073,0.0002986763,0.0002713809,0.0001443674,0.0001421145],"domain_scores_gemma":[0.9983694,0.00004274921,0.0001934488,0.001072557,0.0002230807,0.00009879829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002066752,0.0001231357,0.01227708,0.00002201785,0.000005522163,2.529161e-7,0.0002017252,0.0002630108,0.9865658,0.00001974768,0.0001024838,0.0003985179],"study_design_scores_gemma":[0.0005543525,0.000181128,0.04649294,0.00000404295,0.00002308214,4.429978e-7,0.00003406207,0.00333898,0.9472193,0.00001627538,0.001999306,0.0001361243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589658,0.03056667,0.00883116,0.0006739387,0.00006803932,0.0004137056,0.00006206708,0.00002313411,0.0003954611],"genre_scores_gemma":[0.9391021,0.0002202259,0.05969074,0.000100622,0.00007412768,0.00002213882,0.0007057944,0.00002586896,0.00005840645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05085958,"threshold_uncertainty_score":0.5964499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02237574770117329,"score_gpt":0.2813455017146993,"score_spread":0.258969754013526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}