{"id":"W3044511747","doi":"10.1007/s00401-020-02189-9","title":"Lesion stage-dependent causes for impaired remyelination in MS","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Medizinische Fakultät, Westfälische Wilhelms-Universität Münster; Deutsche Forschungsgemeinschaft; International Progressive MS Alliance; National Multiple Sclerosis Society","keywords":"Remyelination; Multiple sclerosis; Myelin; Lesion; Progenitor cell; Demyelinating disease; Neuroscience; Microglia; Medicine; Oligodendrocyte; Pathology; Biology; Stem cell; Immunology; Central nervous system; Inflammation; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002396578,0.0006230661,0.0004676513,0.0006335404,0.0001725191,0.0002531861,0.0003004613,0.0005059319,0.002065962],"category_scores_gemma":[0.0003097739,0.0001614793,0.0003186168,0.0001755469,0.0003677315,0.0002696866,0.0003461183,0.0005785633,0.0004362529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001557429,"about_ca_system_score_gemma":0.0001761867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002574923,"about_ca_topic_score_gemma":0.0002288464,"domain_scores_codex":[0.9998148,0.0000361686,0.00002942209,0.00004516982,0.00004915596,0.00002539085],"domain_scores_gemma":[0.9996612,0.00005359732,0.0001367889,0.00005267462,0.00003236411,0.00006331113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007171668,0.0002229025,0.006326256,0.0002945185,0.00004462687,0.002563577,0.00008962866,0.0001141397,0.9806801,0.0003105504,0.0001593105,0.00847723],"study_design_scores_gemma":[0.00008814181,0.002802484,0.2347389,0.0001320875,0.0004340189,0.03304746,0.0002118592,0.001394292,0.7180274,0.001782818,0.007297106,0.00004341735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984928,0.007903365,0.003241276,0.0001346287,0.0000567337,0.00009622808,0.0004817529,0.0001802966,0.002977679],"genre_scores_gemma":[0.9948584,0.002639816,0.0009866433,0.00006552362,0.0000249794,0.00003757856,0.0002602642,0.00002284103,0.001103906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002065962,"threshold_uncertainty_score":0.006911337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.142822901197809,"score_gpt":0.3039011348504266,"score_spread":0.1610782336526176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}