{"id":"W3044541666","doi":"10.3389/fcell.2020.00675","title":"Sticking With It: ER-PM Membrane Contact Sites as a Coordinating Nexus for Regulating Lipids and Proteins at the Cell Cortex","year":2020,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Weill Cornell Medical College","keywords":"Membrane contact site; Endoplasmic reticulum; Cell biology; Membrane; Cell cortex; Tethering; Membrane protein; Cell membrane; Integral membrane protein; Biology; Chemistry; Cell; Biochemistry; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004068098,0.0009476741,0.001021915,0.002148967,0.0002860323,0.00129132,0.0009401701,0.001219336,0.003114909],"category_scores_gemma":[0.00041866,0.0003016979,0.0003185053,0.002024554,0.0006717966,0.002047434,0.0009564871,0.001899611,0.003265068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008576477,"about_ca_system_score_gemma":0.0009479929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000729062,"about_ca_topic_score_gemma":0.001186062,"domain_scores_codex":[0.9998876,0.00001599815,0.00001618599,0.00002919428,0.00003623273,0.00001476024],"domain_scores_gemma":[0.9998353,0.00005618266,0.00002305226,0.000007280912,0.00004879601,0.00002951428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009288768,0.00004235458,0.0001252985,0.01141882,0.00005453658,0.0001946134,0.00005459309,0.0003992975,0.00348675,0.009462245,0.03426124,0.9404073],"study_design_scores_gemma":[0.000009538184,0.00003550672,0.0004410172,0.001258416,0.00003914065,0.0005975931,0.00002998521,0.00006854491,0.0005069481,0.00220269,0.9947979,0.00001263045],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009744921,0.9979777,0.0001902804,0.0002424379,0.0002414163,0.000003202818,0.00001715127,0.00001167059,0.001218669],"genre_scores_gemma":[0.0007568944,0.9975552,0.0002162979,0.0002005706,0.0001814298,0.000005924038,0.00004154139,0.000002827579,0.001039365],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003114909,"threshold_uncertainty_score":0.01042038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01422189048436014,"score_gpt":0.2413582666989545,"score_spread":0.2271363762145943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}