{"id":"W3044551817","doi":"10.1186/s12915-020-00819-y","title":"Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site","year":2020,"lang":"en","type":"article","venue":"BMC Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"SLAC National Accelerator Laboratory; Basic Energy Sciences; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Office of Science; National Institutes of Health; U.S. Department of Energy","keywords":"Biology; Antibody-dependent cell-mediated cytotoxicity; Epitope; Effector; Antibody; Co-receptor; Receptor; Cell biology; Binding site; Plasma protein binding; Fc receptor; Glycoprotein; Virology; Function (biology); Immunology; Molecular biology; Genetics; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001099327,0.0003928042,0.0004762153,0.0002903595,0.00059266,0.001916843,0.001192397,0.0009456015,0.001470711],"category_scores_gemma":[0.00294055,0.0002842807,0.0003010018,0.0001751981,0.001763563,0.001443928,0.000521144,0.000995607,0.000673393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008810917,"about_ca_system_score_gemma":0.0006649386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006261028,"about_ca_topic_score_gemma":0.000558183,"domain_scores_codex":[0.9993618,0.0001029042,0.00005739103,0.0001629604,0.000177798,0.000137128],"domain_scores_gemma":[0.998865,0.0004866403,0.0002206266,0.000191008,0.0001354483,0.0001012547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005243551,0.0002003059,0.006046521,0.0004293741,0.00004176166,0.001190131,0.0004704886,0.009204641,0.7976578,0.1619101,0.0009019491,0.0214227],"study_design_scores_gemma":[0.0001813777,0.0007412509,0.008009634,0.0001521655,0.00008141092,0.002626671,0.0005219402,0.06334457,0.8149451,0.08865975,0.02062535,0.0001107931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8963208,0.002339121,0.08268031,0.0005110923,0.0001234171,0.0002936065,0.0001552361,0.0003101207,0.01726627],"genre_scores_gemma":[0.980757,0.0009104096,0.0163184,0.0001676677,0.00003752731,0.0001796814,0.000198578,0.00004146169,0.001389335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001916843,"threshold_uncertainty_score":0.006392777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03447766046606682,"score_gpt":0.2654001550895686,"score_spread":0.2309224946235018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}