{"id":"W3044665335","doi":"10.1038/s41419-020-02803-4","title":"Bioactive DNA from extracellular vesicles and particles","year":2020,"lang":"en","type":"review","venue":"Cell Death and Disease","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Princess Margaret Cancer Foundation; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society; American Society of Clinical Oncology; Conquer Cancer Foundation","keywords":"Biomarker; DNA; Extracellular vesicles; Extracellular vesicle; Biology; Microvesicles; Mediator; Cell biology; RNA; Computational biology; Extracellular; DNA damage; Chemistry; Gene; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006717307,0.0004976861,0.0006343174,0.0000397957,0.0001116324,0.0001024037,0.0002181083,0.0002408739,0.00002757213],"category_scores_gemma":[0.0001535758,0.0004516704,0.0002786093,0.00006972678,0.0001858716,0.000007970751,0.0003040415,0.000159365,0.00004027058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001340786,"about_ca_system_score_gemma":0.0003139151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007830342,"about_ca_topic_score_gemma":7.407837e-7,"domain_scores_codex":[0.9980724,0.0001703746,0.0003453498,0.000953261,0.0001409184,0.0003177287],"domain_scores_gemma":[0.9978051,0.00005136416,0.0001806555,0.0005178436,0.0000259355,0.001419085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001903146,0.0002710904,0.0003729797,0.005563461,0.0002603959,0.0005601767,0.00004696344,3.610562e-7,0.008001136,0.0001725247,0.001205734,0.9833549],"study_design_scores_gemma":[0.0004275322,0.00007040361,0.00008641172,0.0005270126,0.001591904,0.000005337723,0.0000319567,0.00003118331,0.001538027,0.0006387849,0.9944332,0.0006182487],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01241674,0.9859886,0.0001321803,0.00003262221,0.00006669581,0.0004798183,0.0007209176,0.00002852787,0.0001339582],"genre_scores_gemma":[0.01075218,0.9870994,0.0003466964,0.0001134517,0.0003756296,0.00006992625,0.0009512574,0.00008125992,0.0002102037],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9932275,"threshold_uncertainty_score":0.9997935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0210845750710426,"score_gpt":0.2662123709919869,"score_spread":0.2451277959209442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}