{"id":"W3044667119","doi":"10.1097/ftd.0000000000000792","title":"Pharmacokinetic–Pharmacogenomic Model for Chinese Children Treated With Lamotrigine Also Applies for Mexican Children","year":2020,"lang":"en","type":"letter","venue":"Therapeutic Drug Monitoring","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Lamotrigine; Humanities; Medicine; Art; Psychiatry; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001844683,0.001139188,0.001688378,0.0002058162,0.0003966879,0.00007439383,0.0004670613,0.0002995851,0.00001807254],"category_scores_gemma":[0.00001964533,0.0007733701,0.0005258264,0.000284206,0.0002048474,0.00008227126,0.0001128862,0.001332376,0.00001115806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001952478,"about_ca_system_score_gemma":0.0001263342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000353482,"about_ca_topic_score_gemma":4.439354e-7,"domain_scores_codex":[0.9967156,0.00007201124,0.0005712894,0.001090739,0.0004882783,0.001062083],"domain_scores_gemma":[0.9983934,0.0004682032,0.0003329822,0.0003639893,0.0001776392,0.0002637853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0220374,0.002090939,0.1370424,0.006784318,0.05948508,0.000448165,0.002602267,0.006856895,0.1251849,0.00002271381,0.5524095,0.08503553],"study_design_scores_gemma":[0.1431996,0.008783937,0.06469745,0.002721575,0.06747155,0.0006698078,0.0001245997,0.2607035,0.2004002,0.001402533,0.236624,0.01320124],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6710258,0.008319143,0.003875598,0.294598,0.0007230196,0.01837074,0.001616733,0.001217848,0.0002531872],"genre_scores_gemma":[0.8286687,0.001389314,0.001569384,0.1464619,0.0164018,0.002397491,0.0008655322,0.0003916225,0.001854282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3157854,"threshold_uncertainty_score":0.9994717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03390267429883571,"score_gpt":0.3225473605470705,"score_spread":0.2886446862482348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}