{"id":"W3044672998","doi":"10.1093/ecco-jcc/jjaa153","title":"Early Intervention With Vedolizumab and Longer-term Surgery Rates in Crohn’s Disease: Post Hoc Analysis of the GEMINI Phase 3 and Long-term Safety Programmes","year":2020,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Vedolizumab; Medicine; Post-hoc analysis; Hazard ratio; Crohn's disease; Colectomy; Internal medicine; Proportional hazards model; Inflammatory bowel disease; Logistic regression; Surgery; Ulcerative colitis; Disease; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01463893,0.0007102634,0.00161871,0.0005516254,0.0002590592,0.001286421,0.001018273,0.0008272858,0.002582947],"category_scores_gemma":[0.0137953,0.0003223566,0.006317836,0.0005072999,0.0004895353,0.001037987,0.0008284387,0.001801427,0.0002135407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005755592,"about_ca_system_score_gemma":0.0008856821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009950252,"about_ca_topic_score_gemma":0.0009721039,"domain_scores_codex":[0.9916776,0.005621298,0.0003963441,0.001056745,0.0005948113,0.0006530968],"domain_scores_gemma":[0.9741131,0.01923341,0.003171939,0.001931791,0.0006245605,0.000925345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5150272,0.002374005,0.4275726,0.0005423339,0.02075947,0.000290153,0.0003108894,0.006421574,0.002025791,0.0003695207,0.001763631,0.02254296],"study_design_scores_gemma":[0.01372769,0.07857624,0.8623298,0.0001248872,0.0178175,0.0002922397,0.0002610806,0.0204408,0.003383966,0.0006165793,0.002326498,0.0001026915],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976861,0.0006590005,0.0005256255,0.00005899762,0.00003626414,0.00008401774,0.0004943586,0.00001391203,0.0004416698],"genre_scores_gemma":[0.9982761,0.00008554893,0.0003421222,0.00004381375,0.0000310601,0.0001355217,0.0006755101,0.00001394238,0.0003963764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01463893,"threshold_uncertainty_score":0.07741898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008418639771851606,"score_gpt":0.258165452896979,"score_spread":0.2497468131251274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}