{"id":"W3044712566","doi":"10.1161/strokeaha.120.029123","title":"Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke","year":2020,"lang":"en","type":"review","venue":"Stroke","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Stephen's University; Population Health Research Institute","funders":"National Institute on Minority Health and Health Disparities; National Human Genome Research Institute; National Institute for Health and Care Research; National Institute on Aging; National Center for Advancing Translational Sciences; Medical Research Council; Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Centers for Disease Control and Prevention; Jackson State University; NIH Clinical Center; National Center for Research Resources; AstraZeneca; Barts Charity; U.S. Department of Veterans Affairs; Office of Research and Development; Office of Research on Women's Health; National Heart, Lung, and Blood Institute; Canadian Stroke Network; Heart and Stroke Foundation of Canada; Pfizer; Mississippi State Department of Health; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Genome-wide association study; Medicine; Single-nucleotide polymorphism; Stroke (engine); Genetic association; Locus (genetics); Genetics; Meta-analysis; Population; Bonferroni correction; HNF1A; Disease; Bioinformatics; Gene; Internal medicine; Genotype; Biology; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001953997,0.0005495804,0.00503392,0.0007083765,0.00007969877,0.00003215107,0.0005892821,0.000595985,0.00008400551],"category_scores_gemma":[0.001524457,0.0004616341,0.002223487,0.001087712,0.00006942187,0.000007881984,0.000268153,0.0004040547,0.000003480571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002882466,"about_ca_system_score_gemma":0.0004245147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003361852,"about_ca_topic_score_gemma":0.001697933,"domain_scores_codex":[0.995021,0.0009762353,0.001983729,0.0008222164,0.0006927044,0.0005041119],"domain_scores_gemma":[0.9945941,0.0006318219,0.003559878,0.0006969401,0.0004041302,0.0001131451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00002238711,0.001267671,0.5414155,0.0005677119,0.4524523,0.000003287114,0.0005179198,0.0007320217,0.0003714532,0.00001676555,0.0002732267,0.002359821],"study_design_scores_gemma":[0.001280439,0.001109287,0.3333021,0.00007323579,0.5148367,8.468604e-7,0.001611291,0.00001322394,0.0001006849,0.000009081543,0.1466763,0.0009867571],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04672588,0.9239115,0.0008329198,0.0001729899,0.0001324789,0.002402058,0.02508499,0.00001914454,0.0007180458],"genre_scores_gemma":[0.3145176,0.6753397,0.001621817,0.00007682574,0.000133686,0.0005557317,0.004091999,0.0001079194,0.003554801],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2677917,"threshold_uncertainty_score":0.9997835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0650328565249956,"score_gpt":0.3266877168037099,"score_spread":0.2616548602787143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}