{"id":"W3044712566","doi":"10.1161/strokeaha.120.029123","title":"Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke","year":2020,"lang":"en","type":"review","venue":"Stroke","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Stephen's University; Population Health Research Institute","funders":"National Institute on Minority Health and Health Disparities; National Human Genome Research Institute; National Institute for Health and Care Research; National Institute on Aging; National Center for Advancing Translational Sciences; Medical Research Council; Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Centers for Disease Control and Prevention; Jackson State University; NIH Clinical Center; National Center for Research Resources; AstraZeneca; Barts Charity; U.S. Department of Veterans Affairs; Office of Research and Development; Office of Research on Women's Health; National Heart, Lung, and Blood Institute; Canadian Stroke Network; Heart and Stroke Foundation of Canada; Pfizer; Mississippi State Department of Health; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Genome-wide association study; Medicine; Single-nucleotide polymorphism; Stroke (engine); Genetic association; Locus (genetics); Genetics; Meta-analysis; Population; Bonferroni correction; HNF1A; Disease; Bioinformatics; Gene; Internal medicine; Genotype; Biology; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008303354,0.00212014,0.0053277,0.003988014,0.001032328,0.00255469,0.001508992,0.001820153,0.002131412],"category_scores_gemma":[0.01675245,0.001039199,0.02046631,0.005391672,0.000590865,0.0008546644,0.001144966,0.00177324,0.0002488533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00062657,"about_ca_system_score_gemma":0.001059742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006014518,"about_ca_topic_score_gemma":0.008968583,"domain_scores_codex":[0.9932741,0.003417497,0.0007654691,0.00164263,0.000530016,0.0003702996],"domain_scores_gemma":[0.9904481,0.005789335,0.001217337,0.001745372,0.0005107287,0.0002891783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.005536905,0.00006996018,0.331872,0.003306173,0.6413232,0.0006593492,0.0001104818,0.00220847,0.001714648,0.0002320963,0.001547427,0.01141941],"study_design_scores_gemma":[0.0009427425,0.0005070472,0.2712732,0.0008593695,0.7179604,0.0006660437,0.0001260168,0.004036607,0.0008258414,0.0008727549,0.001876854,0.00005311429],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6374689,0.3444621,0.009333503,0.001537017,0.0008894067,0.0001680481,0.003726122,0.0004773922,0.001937482],"genre_scores_gemma":[0.9748678,0.02021451,0.002462667,0.0003954963,0.0002053746,0.0001102279,0.001330457,0.00007057626,0.0003429517],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.008303354,"threshold_uncertainty_score":0.04391289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0650328565249956,"score_gpt":0.3266877168037099,"score_spread":0.2616548602787143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}