{"id":"W3044742024","doi":"10.1101/2020.07.27.223545","title":"Enhanced Brain Imaging Genetics in UK Biobank","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Actua; Simon Fraser University","funders":"NIHR Oxford Biomedical Research Centre; Western Canada Research Grid; Medical Research Council; Biomedical Research Council; National Institute for Health and Care Research; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Biobank; Genome-wide association study; Phenotype; Biology; Genetics; Neuroimaging; Neuroscience; Evolutionary biology; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004597976,0.00059304,0.0008860657,0.00567388,0.000994403,0.003132899,0.001510364,0.001550397,0.09595863],"category_scores_gemma":[0.0385671,0.0006677315,0.0005016907,0.008960208,0.0004790312,0.001891522,0.00355501,0.001012708,0.03058085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002653226,"about_ca_system_score_gemma":0.003625395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02355988,"about_ca_topic_score_gemma":0.01760028,"domain_scores_codex":[0.9950966,0.00127624,0.001079983,0.001001697,0.001092039,0.000453359],"domain_scores_gemma":[0.9667003,0.01015727,0.005908169,0.00597297,0.007532992,0.003728338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0008751667,0.00006142102,0.05415935,0.0006592837,0.0001106018,0.0007868875,0.0005134442,0.0003409483,0.000471644,0.005485275,0.8557153,0.08082069],"study_design_scores_gemma":[0.000445448,0.0001385967,0.1498831,0.0009225074,0.0001151971,0.001245845,0.000320926,0.000775076,0.0008080342,0.005987447,0.8392133,0.0001444815],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.03692869,0.003111937,0.007842433,0.008436781,0.000836635,0.0008425866,0.8920355,0.003146636,0.04681884],"genre_scores_gemma":[0.1104244,0.003587301,0.02377433,0.00712362,0.001236391,0.004161494,0.7867625,0.001923205,0.06100687],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.09595863,"threshold_uncertainty_score":0.3210136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245152128740032,"score_gpt":0.242573987291375,"score_spread":0.2301224660039747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}