{"id":"W3044778137","doi":"10.1016/j.celrep.2020.107927","title":"Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University; Canada Research Chairs","keywords":"Klebsiella pneumoniae; Antibiotics; Bacteria; Biology; Drug discovery; Microbiology; Human pathogen; Gene; Biochemistry; Escherichia coli; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385183,0.000208839,0.0002737388,0.00002634393,0.0000605803,0.00005998463,0.00008698258,0.0002020496,0.000005915198],"category_scores_gemma":[0.00005493299,0.000223014,0.00004041028,0.00006323455,0.0001351529,0.000005822615,0.0002635288,0.0001243305,3.913061e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004918003,"about_ca_system_score_gemma":0.00003353272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008328132,"about_ca_topic_score_gemma":0.000005863677,"domain_scores_codex":[0.9985288,0.00005388754,0.0004383581,0.0006039146,0.00009833596,0.0002767271],"domain_scores_gemma":[0.9993182,0.000009022641,0.0001934492,0.0002737081,0.00003320897,0.0001723703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002248374,0.00002638825,0.1893583,0.00007198532,0.00001411441,0.0003895319,0.00004643186,0.0000025378,0.8097673,0.000001624049,0.0001473631,0.0001519254],"study_design_scores_gemma":[0.000561937,0.0001090731,0.1912704,0.00006151509,0.00002538335,0.0002200305,0.00003523593,0.00002040941,0.8054793,0.00004008715,0.001842734,0.0003339233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980577,0.000517661,0.00007673545,0.00009933294,0.00006958238,0.0002072132,0.000007124461,0.00001620392,0.0009484513],"genre_scores_gemma":[0.9974871,0.0002997109,0.001567491,0.0002257384,0.0002167595,0.000002604532,0.00007616277,0.00003397457,0.00009043751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004287999,"threshold_uncertainty_score":0.9094247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008489816093916212,"score_gpt":0.2225630961213144,"score_spread":0.2140732800273982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}