{"id":"W3044778137","doi":"10.1016/j.celrep.2020.107927","title":"Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University; Canada Research Chairs","keywords":"Klebsiella pneumoniae; Antibiotics; Bacteria; Biology; Drug discovery; Microbiology; Human pathogen; Gene; Biochemistry; Escherichia coli; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002257407,0.000470315,0.0003901787,0.000425278,0.000137876,0.0003259926,0.0001855625,0.0003167958,0.0009379686],"category_scores_gemma":[0.0002959687,0.0001320699,0.0003158091,0.0005325338,0.0001832638,0.0001599865,0.0002282569,0.0002862569,0.0003310513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002377747,"about_ca_system_score_gemma":0.0004738733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079754,"about_ca_topic_score_gemma":0.002204047,"domain_scores_codex":[0.9997533,0.00005066337,0.00002265914,0.00003609543,0.0001013698,0.0000359253],"domain_scores_gemma":[0.99989,0.00002624893,0.00002785186,0.0000121718,0.00002569614,0.00001798035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001412183,0.00006045109,0.0002738847,0.0000778406,0.000008485844,0.00006520176,0.000008354728,0.0002797083,0.9940018,0.00005929186,0.00007732822,0.004946342],"study_design_scores_gemma":[0.00001586187,0.0007275668,0.001328017,0.000007914166,0.00002949651,0.0002118511,0.0000173777,0.0004563956,0.9952047,0.00004020192,0.001954627,0.00000596094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761904,0.0061236,0.01191335,0.0003988243,0.00003720415,0.0001301331,0.001659211,0.000337744,0.003209514],"genre_scores_gemma":[0.978177,0.0038997,0.01121968,0.0001975442,0.00001194464,0.00006273826,0.002158204,0.00004444153,0.004228842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079754,"threshold_uncertainty_score":0.003137827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008489816093916212,"score_gpt":0.2225630961213144,"score_spread":0.2140732800273982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}