{"id":"W3044815386","doi":"10.1371/journal.pone.0236187","title":"The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"Wallenberg Centre for Molecular and Translational Medicine; Barncancerfonden; Göteborgs Universitet; China Scholarship Council; Knut och Alice Wallenbergs Stiftelse; Sahlgrenska Universitetssjukhuset; Cancer Research UK; Vetenskapsrådet; Johan Jansson Foundation; Stiftelserna Wilhelm och Martina Lundgrens; Swedish Cancer Foundation","keywords":"Breast cancer; Biology; Cancer; Cancer research; Cancer stem cell; Mevalonate pathway; Cancer cell; Genetics; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001121795,0.0001269043,0.0002484288,0.00001964274,0.00002502464,0.00000811224,0.0001048414,0.00007785548,0.0000175511],"category_scores_gemma":[0.00000650878,0.0001012043,0.00003530334,0.00006640353,0.0001253184,0.000006203916,0.0001046941,0.00007373525,1.895617e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001246103,"about_ca_system_score_gemma":0.0001372895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004915043,"about_ca_topic_score_gemma":0.0004600739,"domain_scores_codex":[0.9990965,0.00003027159,0.0002305377,0.0002651139,0.0002032652,0.0001743071],"domain_scores_gemma":[0.9995278,0.00001468145,0.0001202505,0.0001425971,0.00009519015,0.00009946927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006181793,0.0002424333,0.00747354,0.0003304472,0.0001997747,6.053479e-8,0.001106787,0.00002404011,0.987099,0.0000240778,0.001771452,0.001110244],"study_design_scores_gemma":[0.003133851,0.0002106432,0.02717714,0.0001737496,0.0003300443,0.000001303283,0.0003921182,0.003368964,0.9548816,0.00003455371,0.009977273,0.0003187516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711798,0.02627142,0.00002237819,0.001311188,0.000231681,0.0002644914,0.0006225395,0.00000254047,0.00009395122],"genre_scores_gemma":[0.9792652,0.01869113,0.0001515802,0.000326519,0.001126217,0.00009128858,0.000006377598,0.0000180943,0.0003236082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03221736,"threshold_uncertainty_score":0.4126992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02025482965289051,"score_gpt":0.2245447660655256,"score_spread":0.204289936412635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}