{"id":"W3044815386","doi":"10.1371/journal.pone.0236187","title":"The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"Wallenberg Centre for Molecular and Translational Medicine; Barncancerfonden; Göteborgs Universitet; China Scholarship Council; Knut och Alice Wallenbergs Stiftelse; Sahlgrenska Universitetssjukhuset; Cancer Research UK; Vetenskapsrådet; Johan Jansson Foundation; Stiftelserna Wilhelm och Martina Lundgrens; Swedish Cancer Foundation","keywords":"Breast cancer; Biology; Cancer; Cancer research; Cancer stem cell; Mevalonate pathway; Cancer cell; Genetics; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002611288,0.0002839773,0.0004205045,0.0006995858,0.0002460768,0.0004692236,0.0002184226,0.0002291409,0.001092792],"category_scores_gemma":[0.0001105083,0.0001699019,0.0002792048,0.0003580075,0.0003126617,0.0001992232,0.0002960412,0.0006372234,0.0003239485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003075099,"about_ca_system_score_gemma":0.0003094937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009988738,"about_ca_topic_score_gemma":0.002165973,"domain_scores_codex":[0.9997804,0.00003295894,0.00001811693,0.00005137267,0.00007580697,0.00004136028],"domain_scores_gemma":[0.999893,0.00001593295,0.00002975336,0.00001628958,0.00001565692,0.00002938569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001157349,0.00001518262,0.0009417163,0.00004554986,0.000008925425,0.00002225486,0.00002161837,0.00004088527,0.9974963,0.00006640575,0.00002530275,0.001200191],"study_design_scores_gemma":[0.000007957383,0.0002903322,0.01456736,0.000008948672,0.00004479242,0.0001890863,0.0001068324,0.000608376,0.9813225,0.0001005072,0.002746519,0.000006746797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815626,0.004022167,0.01085868,0.0002414967,0.00003906285,0.00006959403,0.001678106,0.0002071259,0.001321073],"genre_scores_gemma":[0.9877174,0.001945942,0.005062203,0.00008472744,0.000009544308,0.00007714794,0.002087432,0.00003982157,0.002975728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092792,"threshold_uncertainty_score":0.003655732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02025482965289051,"score_gpt":0.2245447660655256,"score_spread":0.204289936412635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}