{"id":"W3044938198","doi":"10.1200/jco.19.02983","title":"Comprehensive Genomic Analysis in NRG Oncology/RTOG 9802: A Phase III Trial of Radiation Versus Radiation Plus Procarbazine, Lomustine (CCNU), and Vincristine in High-Risk Low-Grade Glioma","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":222,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; Ottawa Hospital; Ottawa Regional Cancer Foundation; Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Lomustine; Medicine; Procarbazine; Oncology; Internal medicine; Hazard ratio; Proportional hazards model; Progression-free survival; Glioma; Chemoradiotherapy; Radiation therapy; Vincristine; Chemotherapy; Cancer research; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001635135,0.0002333345,0.003135118,0.0007637354,0.00002984459,0.000008683358,0.0001280422,0.0004757417,0.00004632222],"category_scores_gemma":[0.004461287,0.0001884921,0.0005036843,0.001120017,0.0001821552,0.0001057101,0.00005912829,0.0008543057,0.000003857534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006679762,"about_ca_system_score_gemma":0.001301956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004503349,"about_ca_topic_score_gemma":0.0003978599,"domain_scores_codex":[0.9944115,0.0009168683,0.003676972,0.0003675219,0.000361573,0.000265592],"domain_scores_gemma":[0.99177,0.004021314,0.00331877,0.0001742415,0.0002788659,0.0004367518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5809745,0.01441991,0.1391702,0.000101985,0.004077865,0.003613791,0.0009545624,0.003702751,0.002600228,0.00005035229,0.0007177819,0.2496161],"study_design_scores_gemma":[0.5545276,0.04377932,0.3853081,0.00004803069,0.004128325,0.0000388125,0.0001906486,0.009661756,0.0003710889,0.00003452791,0.001778349,0.0001333772],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899072,0.001373083,0.00007629202,0.007032353,0.0006596205,0.0008616817,0.00002765376,0.000008221338,0.00005390056],"genre_scores_gemma":[0.9952364,0.002355074,0.0008577579,0.000462473,0.0009963794,0.00002029779,0.00005288777,0.00001722061,0.000001494618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2494827,"threshold_uncertainty_score":0.7686484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08840937308299648,"score_gpt":0.4350052083232139,"score_spread":0.3465958352402174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}