{"id":"W3044938198","doi":"10.1200/jco.19.02983","title":"Comprehensive Genomic Analysis in NRG Oncology/RTOG 9802: A Phase III Trial of Radiation Versus Radiation Plus Procarbazine, Lomustine (CCNU), and Vincristine in High-Risk Low-Grade Glioma","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":222,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; Ottawa Hospital; Ottawa Regional Cancer Foundation; Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Lomustine; Medicine; Procarbazine; Oncology; Internal medicine; Hazard ratio; Proportional hazards model; Progression-free survival; Glioma; Chemoradiotherapy; Radiation therapy; Vincristine; Chemotherapy; Cancer research; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009781478,0.0006906356,0.000796591,0.0003494426,0.0002234566,0.000502711,0.0004610058,0.0003976973,0.001938606],"category_scores_gemma":[0.0007441453,0.0002863901,0.0005681452,0.0003500618,0.0005292575,0.0002938565,0.0002906717,0.0008843725,0.000265523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009290166,"about_ca_system_score_gemma":0.001071094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00149372,"about_ca_topic_score_gemma":0.00776745,"domain_scores_codex":[0.9995742,0.0002078283,0.00001747688,0.00009012417,0.00005884105,0.00005146019],"domain_scores_gemma":[0.9997922,0.00003535588,0.00006848128,0.00001609936,0.00001165504,0.00007623765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5673113,0.0168122,0.03651394,0.001648547,0.003328013,0.0003230108,0.0005646934,0.008593014,0.09429353,0.001103963,0.008676192,0.2608316],"study_design_scores_gemma":[0.3410912,0.4179556,0.1960061,0.0001572736,0.004930843,0.0009665259,0.000303004,0.005683897,0.01698071,0.001255785,0.01455843,0.0001106912],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951574,0.001185552,0.0005018692,0.0002813403,0.00003574945,0.000677483,0.0009084847,0.00005933034,0.001192834],"genre_scores_gemma":[0.9929813,0.0009998986,0.001539716,0.0004215019,0.00004826931,0.000814213,0.001939828,0.00002667553,0.001228521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001938606,"threshold_uncertainty_score":0.00674051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08840937308299648,"score_gpt":0.4350052083232139,"score_spread":0.3465958352402174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}