{"id":"W3044948246","doi":"10.1371/journal.pone.0235756","title":"Conserved mammalian modularity of quantitative trait loci revealed human functional orthologs in blood pressure control","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Heart and Stroke Foundation of Canada","keywords":"Quantitative trait locus; Biology; Genome-wide association study; Single-nucleotide polymorphism; Genetics; Expression quantitative trait loci; Phenotype; Genome; Genetic association; Human genome; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003243647,0.0002277335,0.0002157148,0.0003511637,0.0001195711,0.0002307524,0.00018325,0.0002065729,0.001197144],"category_scores_gemma":[0.0004269813,0.0001546022,0.0003111048,0.0002748587,0.0004038442,0.0001264214,0.0002989327,0.0003777497,0.0001175438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001686237,"about_ca_system_score_gemma":0.0001955328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006297757,"about_ca_topic_score_gemma":0.0006932958,"domain_scores_codex":[0.9998326,0.00002859088,0.00001136709,0.00006698834,0.00003514475,0.00002523579],"domain_scores_gemma":[0.9998,0.00007724263,0.00005666253,0.0000299315,0.00001277446,0.00002343211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005997239,0.00004678557,0.01373469,0.00005246505,0.00005640166,0.000502163,0.0002075504,0.001014564,0.9695001,0.002702378,0.0000881308,0.0114951],"study_design_scores_gemma":[0.0002072288,0.001151368,0.5700952,0.00005319986,0.0002853934,0.006435219,0.0002612465,0.01701814,0.3866273,0.006199376,0.01157826,0.00008812189],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854866,0.0003660144,0.01294318,0.00009953549,0.00001226142,0.00001754729,0.0002709505,0.00008065067,0.0007231648],"genre_scores_gemma":[0.9936,0.0001290783,0.005684316,0.00006352129,0.00000896088,0.00001177808,0.0001879702,0.00001495589,0.0002993044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001197144,"threshold_uncertainty_score":0.004004776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0624083529083487,"score_gpt":0.2576506674932847,"score_spread":0.195242314584936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}