{"id":"W3044950861","doi":"10.1002/mds.28202","title":"Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease","year":2020,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; College of Engineering, Michigan State University; National Institutes of Health; U.S. Department of Veterans Affairs; H. Lundbeck A/S; Weston Brain Institute; Michigan State University; Biogen; National Institute of Mental Health; Pfizer; Alzheimer's Association; Michael J. Fox Foundation for Parkinson's Research; Bristol-Myers Squibb; Axial Biotherapeutics; U.S. Department of Defense","keywords":"Quinolinic acid; Kynurenine; Kynurenine pathway; Kynurenic acid; Substantia nigra; Cerebrospinal fluid; Parkinson's disease; Metabolite; Internal medicine; Medicine; Central nervous system disease; Neuroprotection; Endocrinology; Pathology; Disease; Chemistry; Tryptophan; Biochemistry; Glutamate receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002783829,0.0003620669,0.0004270245,0.0007545839,0.0002844518,0.0004959549,0.0001878945,0.0004836236,0.000938944],"category_scores_gemma":[0.0008268148,0.000184442,0.0002040531,0.0005391557,0.0003281144,0.0002267634,0.0003603849,0.0002538689,0.0001337706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002050808,"about_ca_system_score_gemma":0.0001289156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001064427,"about_ca_topic_score_gemma":0.001108885,"domain_scores_codex":[0.9997919,0.00003651034,0.00004265782,0.00006266993,0.00004419138,0.00002199298],"domain_scores_gemma":[0.9992489,0.0001030595,0.0004688106,0.00002499664,0.00007303023,0.0000811736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007411482,0.00004180889,0.9906634,0.00003535075,0.0001248874,0.0002873855,0.00006665107,0.00005038913,0.00568769,0.000009152718,0.00003072038,0.00226143],"study_design_scores_gemma":[0.000008061968,0.0001470938,0.9981933,0.000003898001,0.00003745681,0.0009979594,0.00003751659,0.00007709872,0.0004139227,0.00002073381,0.00006089241,0.000002063914],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993252,0.0004228149,0.00006046917,0.000009752158,0.000001287059,0.000003626991,0.00008716974,0.000002685503,0.00008705484],"genre_scores_gemma":[0.9995813,0.00009997984,0.0001049116,0.000009723061,0.000003846207,0.000003430047,0.0001482674,0.000001063439,0.00004754591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064427,"threshold_uncertainty_score":0.003141105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398866498633532,"score_gpt":0.2178828725245477,"score_spread":0.2038942075382124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}