{"id":"W3044950861","doi":"10.1002/mds.28202","title":"Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease","year":2020,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; College of Engineering, Michigan State University; National Institutes of Health; U.S. Department of Veterans Affairs; H. Lundbeck A/S; Weston Brain Institute; Michigan State University; Biogen; National Institute of Mental Health; Pfizer; Alzheimer's Association; Michael J. Fox Foundation for Parkinson's Research; Bristol-Myers Squibb; Axial Biotherapeutics; U.S. Department of Defense","keywords":"Quinolinic acid; Kynurenine; Kynurenine pathway; Kynurenic acid; Substantia nigra; Cerebrospinal fluid; Parkinson's disease; Metabolite; Internal medicine; Medicine; Central nervous system disease; Neuroprotection; Endocrinology; Pathology; Disease; Chemistry; Tryptophan; Biochemistry; Glutamate receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007695358,0.0002581073,0.0002823464,0.0001116162,0.0001036456,0.00006211233,0.0002139141,0.00005728627,0.00007052108],"category_scores_gemma":[0.000494318,0.0002240034,0.00005783006,0.0005673015,0.0002328056,0.0001752859,0.00008995808,0.0001699314,0.000009341024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002653355,"about_ca_system_score_gemma":0.00003233342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001867062,"about_ca_topic_score_gemma":0.0002586564,"domain_scores_codex":[0.9981797,0.0001829452,0.0002172377,0.000663285,0.0002878962,0.0004689471],"domain_scores_gemma":[0.999317,0.000121711,0.0001180212,0.0001723755,0.00001152521,0.0002594059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004994555,0.0007534329,0.9682251,0.00007096601,0.0000358797,0.0002442584,0.001863612,0.0002185294,0.0169744,0.004026803,0.00106364,0.006023903],"study_design_scores_gemma":[0.004190075,0.0002914059,0.9749187,0.0000454617,0.00002335468,1.924188e-7,0.001120473,0.001255895,0.003689297,0.0110077,0.002917998,0.0005394579],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890198,0.0005524835,0.00006944231,0.009183867,0.0000517804,0.0004468367,0.00006085602,0.0001284251,0.0004865318],"genre_scores_gemma":[0.9745408,0.0002318964,0.00001998704,0.02500107,0.00001669225,0.00007760268,0.00001184575,0.00003064608,0.00006941144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0158172,"threshold_uncertainty_score":0.9134592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398866498633532,"score_gpt":0.2178828725245477,"score_spread":0.2038942075382124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}