{"id":"W3044963562","doi":"10.1634/theoncologist.2020-0502","title":"Tepotinib Efficacy in a Patient with Non-Small Cell Lung Cancer with Brain Metastasis Harboring an <i>HLA-DRB1-MET</i> Gene Fusion","year":2020,"lang":"en","type":"article","venue":"The Oncologist","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"EMD Serono","keywords":"Crizotinib; Cabozantinib; Fusion gene; ROS1; Medicine; Lung cancer; Cancer research; KRAS; Erlotinib; Clinical trial; Oncology; Tyrosine kinase; Gene; Cancer; Internal medicine; Bioinformatics; Biology; Genetics; Receptor; Colorectal cancer; Epidermal growth factor receptor; Adenocarcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001009192,0.0003076228,0.000568136,0.0002044126,0.0004264255,0.0003425048,0.0001894768,0.0006649145,0.0005904031],"category_scores_gemma":[0.0004307221,0.0001324872,0.0003250046,0.0001627688,0.0001755242,0.0002491805,0.0001697681,0.0008251199,0.0002174314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003118657,"about_ca_system_score_gemma":0.0001886285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005053523,"about_ca_topic_score_gemma":0.001298288,"domain_scores_codex":[0.9999261,0.00001195987,0.00001173184,0.00001737312,0.00001264403,0.00002029923],"domain_scores_gemma":[0.9998598,0.00004339447,0.00002083826,0.000007634696,0.000007737343,0.00006050082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.01553552,0.00370624,0.09279823,0.0005022887,0.0003706386,0.5976064,0.00113744,0.00387247,0.1629893,0.0004655745,0.002556897,0.118459],"study_design_scores_gemma":[0.001719375,0.04345651,0.1897568,0.00006436428,0.0005536924,0.7016425,0.0004226012,0.008038475,0.04345184,0.00040655,0.01035466,0.0001326352],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996681,0.001467511,0.0001451025,0.0004553458,0.00002741288,0.00001744846,0.00006755209,0.00001545176,0.001123044],"genre_scores_gemma":[0.998694,0.0005543457,0.0001095758,0.0001652935,0.00002994513,0.000004027934,0.00007799584,0.000002847068,0.0003619496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006649145,"threshold_uncertainty_score":0.002262771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02349775064962089,"score_gpt":0.3182121643940267,"score_spread":0.2947144137444058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}