{"id":"W3044981813","doi":"10.1177/0269881120936891","title":"Long-term administration of cariprazine increases locus coeruleus noradrenergic neurons activity and serotonin <sub>1A</sub> receptor neurotransmission in the hippocampus","year":2020,"lang":"en","type":"article","venue":"Journal of Psychopharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Locus coeruleus; 5-HT receptor; Neurotransmission; Internal medicine; Agonist; Escitalopram; Neuroscience; Hippocampus; Pharmacology; Serotonin; Endocrinology; Psychology; Chemistry; Antidepressant; Receptor; Medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003540791,0.000301583,0.000498231,0.0002171345,0.00009837122,0.00005219057,0.0006539418,0.0001312153,0.00009476086],"category_scores_gemma":[0.000209928,0.0002351625,0.0001451363,0.0007203681,0.0003264544,0.0004560478,0.0000415454,0.0009817092,0.000007929851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003182665,"about_ca_system_score_gemma":0.0001999176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000086541,"about_ca_topic_score_gemma":0.00001044477,"domain_scores_codex":[0.9965567,0.001307473,0.0008124129,0.0004523896,0.000522926,0.0003481045],"domain_scores_gemma":[0.9981546,0.0004766832,0.00075008,0.0001949461,0.0001130881,0.0003106061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003349347,0.0006543277,0.008188259,0.00007906688,0.000008510058,0.0007629324,0.0003478346,0.00008248908,0.9713438,0.000004540501,0.0003304872,0.01484847],"study_design_scores_gemma":[0.003567551,0.002497041,0.09256058,0.00005083818,0.0001054687,0.001040321,0.00001538484,0.00005104245,0.8997075,0.00003017308,0.0001842408,0.0001898339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926198,0.0001415505,0.00005812887,0.005784822,0.0006225459,0.0007099137,0.00002398563,0.00002048921,0.00001872992],"genre_scores_gemma":[0.9954987,0.0009191735,0.00003793559,0.003291057,0.0001882177,0.00003017381,0.000001053809,0.00003197482,0.000001761751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08437232,"threshold_uncertainty_score":0.9589649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03389735977487502,"score_gpt":0.3251096369517973,"score_spread":0.2912122771769223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}