{"id":"W3044994694","doi":"10.1186/s12987-020-00209-0","title":"Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human","year":2020,"lang":"en","type":"article","venue":"Fluids and Barriers of the CNS","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Transcytosis; Receptor; Insulin-like growth factor 1 receptor; Transferrin receptor; Blood–brain barrier; Biology; Human brain; LRP1; LDL receptor; Cell biology; Endocrinology; Endocytosis; Neuroscience; Biochemistry; Lipoprotein; Central nervous system; Growth factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000160433,0.0001962923,0.0003229121,0.0005617453,0.0001991186,0.00047987,0.0001211959,0.000330092,0.001695986],"category_scores_gemma":[0.000199727,0.0001845571,0.0004116571,0.0003793489,0.0001992145,0.00018479,0.0001834257,0.0005068753,0.0005783056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001767869,"about_ca_system_score_gemma":0.0001740393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001133308,"about_ca_topic_score_gemma":0.001508928,"domain_scores_codex":[0.9997697,0.000009463935,0.00001067481,0.0001113578,0.00005255598,0.00004613258],"domain_scores_gemma":[0.9999236,0.00001615408,0.00002187872,0.00000661007,0.00001569189,0.00001593596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000494078,0.00001933626,0.006576207,0.0002739692,0.00008041125,0.0002230113,0.0001601922,0.0001797183,0.9825256,0.0002952177,0.0006280949,0.008544078],"study_design_scores_gemma":[0.00009447124,0.0005779955,0.4894626,0.000182697,0.0005395939,0.003976861,0.0008263296,0.003993482,0.4570408,0.0008640667,0.04235945,0.0000817656],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593629,0.009551483,0.01111308,0.0002301747,0.00008497408,0.00004967293,0.01664316,0.0002491354,0.002715412],"genre_scores_gemma":[0.9678574,0.004826816,0.007581849,0.0004158693,0.00003206482,0.0002054991,0.01291966,0.0001598842,0.006000915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001695986,"threshold_uncertainty_score":0.005673647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134867520454187,"score_gpt":0.2263161090649517,"score_spread":0.212829357019533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}