{"id":"W3045084972","doi":"10.3390/genes11080856","title":"Literature Review of BARD1 as a Cancer Predisposing Gene with a Focus on Breast and Ovarian Cancers","year":2020,"lang":"en","type":"review","venue":"Genes","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Ovarian cancer; Breast cancer; Focus (optics); Medicine; Oncology; Gene; Internal medicine; Cancer; Cancer research; Gynecology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001206018,0.0004721318,0.002097722,0.000127515,0.00004660664,0.00002375665,0.0001167187,0.0002050697,0.0001871599],"category_scores_gemma":[0.0000159321,0.0003170013,0.0002620288,0.000620965,0.00009523545,0.00004451152,0.0000322362,0.0003752723,0.000006975827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003579294,"about_ca_system_score_gemma":0.001617387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001095371,"about_ca_topic_score_gemma":0.00001639139,"domain_scores_codex":[0.9981912,0.000114136,0.0005120611,0.0005669959,0.0003834011,0.0002322577],"domain_scores_gemma":[0.9986941,0.00004620532,0.0004342993,0.000432453,0.0001760839,0.0002168279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000166259,0.00001509938,0.000007238507,0.1708954,0.0004935401,0.0001426768,0.00009540964,3.703072e-7,0.00001908466,0.00003433365,0.001245328,0.8268853],"study_design_scores_gemma":[0.0004483297,0.0002094191,0.00000567786,0.4187043,0.001170304,0.001393436,0.000002486846,5.611206e-7,0.00006366502,0.000006630256,0.5778162,0.0001789644],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000004930198,0.9950404,0.00001358605,0.001440789,0.0001695905,0.001544675,0.0009596039,0.0000409941,0.0007854612],"genre_scores_gemma":[0.000005789528,0.9962086,0.0004513577,0.001530716,0.00087824,0.0005085749,0.0001541893,0.00009168037,0.0001708592],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8267063,"threshold_uncertainty_score":0.9999282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02759821705346851,"score_gpt":0.3434438496598919,"score_spread":0.3158456326064234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}