{"id":"W3045095839","doi":"10.1111/cts.12842","title":"Population Pharmacokinetics of Candesartan in Patients with Chronic Heart Failure","year":2020,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Candesartan; NONMEM; Medicine; Pharmacokinetics; Heart failure; Renal function; Population; Internal medicine; Population pharmacokinetics; Dosing; Pharmacology; Cardiology; Urology; Blood pressure; Angiotensin II","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001705398,0.0002681148,0.0006941443,0.0001874505,0.0001214629,0.0006148466,0.0002778995,0.0004061481,0.0004695616],"category_scores_gemma":[0.003242375,0.0001595776,0.0006013546,0.0002051837,0.000153662,0.0003441558,0.0002026717,0.0006282877,0.00009043376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000269995,"about_ca_system_score_gemma":0.0006205075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002939363,"about_ca_topic_score_gemma":0.00185415,"domain_scores_codex":[0.9994855,0.0002968845,0.00002233358,0.00009367793,0.00006387921,0.00003783036],"domain_scores_gemma":[0.9989127,0.0006498272,0.0001821706,0.0001247266,0.00007744769,0.00005311198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005165569,0.0007651768,0.7358091,0.0001485924,0.002670994,0.001093494,0.0004138924,0.2089936,0.005799631,0.00153667,0.00114034,0.03646285],"study_design_scores_gemma":[0.0005530248,0.003520007,0.4267139,0.00004181201,0.0008759312,0.0008730589,0.0002590757,0.5600176,0.001856452,0.003488831,0.001725995,0.00007427174],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914459,0.0004060179,0.007298488,0.0001272089,0.00000926398,0.00002277675,0.0002403236,0.00003400832,0.0004159801],"genre_scores_gemma":[0.998252,0.0001396032,0.001242407,0.00003178832,0.000008625389,0.00001983738,0.0002029078,0.00000409053,0.00009892834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002939363,"threshold_uncertainty_score":0.009019077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298701724452341,"score_gpt":0.3327019885354969,"score_spread":0.3028318160902628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}