{"id":"W3045095839","doi":"10.1111/cts.12842","title":"Population Pharmacokinetics of Candesartan in Patients with Chronic Heart Failure","year":2020,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Candesartan; NONMEM; Medicine; Pharmacokinetics; Heart failure; Renal function; Population; Internal medicine; Population pharmacokinetics; Dosing; Pharmacology; Cardiology; Urology; Blood pressure; Angiotensin II","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001476449,0.00004781065,0.0001343781,0.00003248498,0.00002820895,0.000004915366,0.00002698534,0.00001852331,0.00004122992],"category_scores_gemma":[0.00002002539,0.00003301797,0.00002043039,0.0002628783,0.0002047567,0.00008233227,0.00000752325,0.00006246531,0.000001912398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006310423,"about_ca_system_score_gemma":0.00007564546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001891568,"about_ca_topic_score_gemma":0.00004733917,"domain_scores_codex":[0.9992774,0.0000117433,0.0002033403,0.0001680471,0.0002506944,0.00008881623],"domain_scores_gemma":[0.9997406,0.00003257295,0.0000240609,0.00004080151,0.00004416718,0.0001177896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001104139,0.00009342415,0.9956785,0.00002032882,0.000005811094,6.10779e-7,0.00003363756,0.00003393098,0.00005609095,0.000316062,0.00004925321,0.003601933],"study_design_scores_gemma":[0.002691212,0.0004686412,0.9935801,0.00002589226,0.00002323452,2.080693e-7,0.000002636311,0.0009640928,0.00004086259,0.00004769154,0.002119223,0.00003619694],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843193,0.00002630956,0.00008577274,0.01521114,0.00001643968,0.0002519808,0.000003333811,0.000006943286,0.00007879093],"genre_scores_gemma":[0.9969404,0.000005221977,0.002671504,0.0003230471,0.00003519551,0.000001915821,0.00001474717,0.000002224152,0.000005692536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0148881,"threshold_uncertainty_score":0.1346434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298701724452341,"score_gpt":0.3327019885354969,"score_spread":0.3028318160902628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}