{"id":"W3045161032","doi":"10.1038/s41598-020-68848-9","title":"Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of Alberta; Health Sciences Centre; University of British Columbia","funders":"National Institute of Mental Health; National Institute on Aging; National Natural Science Foundation of China; Priority Academic Program Development of Jiangsu Higher Education Institutions; Medical Research Council; Xuzhou Medical University; Natural Science Foundation of Jiangsu Province; China Postdoctoral Science Foundation; Ministry of Education of the People's Republic of China; Rosetrees Trust; Parkinson's UK; National Institute for Health and Care Research; National Bureau of Statistics of China","keywords":"Mendelian randomization; Amyotrophic lateral sclerosis; Telomere; C9orf72; Association (psychology); Medicine; Causal inference; Genome-wide association study; Genetics; Biology; Bioinformatics; Disease; Psychology; Pathology; Single-nucleotide polymorphism; Genotype; Gene; Allele; Genetic variants; Trinucleotide repeat expansion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08294965,0.00127429,0.002594262,0.001453405,0.0008739034,0.001988731,0.001758586,0.001619834,0.0037656],"category_scores_gemma":[0.1728389,0.0007044006,0.002382034,0.001991534,0.003274557,0.001658023,0.001370507,0.001624327,0.0003093763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007217609,"about_ca_system_score_gemma":0.001315071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002524849,"about_ca_topic_score_gemma":0.002003428,"domain_scores_codex":[0.8767089,0.0967756,0.004789914,0.01425966,0.00568356,0.001782474],"domain_scores_gemma":[0.880572,0.09261438,0.008786794,0.01612915,0.001404637,0.0004930404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02180455,0.000571475,0.5808015,0.002547604,0.0485722,0.009435982,0.003255482,0.02456096,0.0143203,0.1732407,0.006201684,0.1146876],"study_design_scores_gemma":[0.01110799,0.0109892,0.3464776,0.0009419035,0.03393301,0.0159645,0.00123332,0.1767571,0.008438137,0.367548,0.02601176,0.0005974885],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6203916,0.004687652,0.3610283,0.002194989,0.0006743504,0.001806871,0.001770626,0.0009743699,0.006471342],"genre_scores_gemma":[0.9548781,0.0004547134,0.04194974,0.0007439423,0.0001142119,0.0008742883,0.000377265,0.00005507515,0.0005526465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08294965,"threshold_uncertainty_score":0.4386849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03714985913438223,"score_gpt":0.2691677661475057,"score_spread":0.2320179070131235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}