{"id":"W3045186659","doi":"10.1016/j.jsb.2020.107582","title":"In-depth NMR characterization of Rab4a structure, nucleotide exchange and hydrolysis kinetics reveals an atypical GTPase profile","year":2020,"lang":"en","type":"article","venue":"Journal of Structural Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"GTPase; GTP'; Rab; Nucleotide; Guanine nucleotide exchange factor; Endosome; Regulator; Small GTPase; Biochemistry; Mutant; Context (archaeology); Chemistry; Cell biology; Guanosine diphosphate; Biology; Biophysics; Guanosine triphosphate; Signal transduction; Enzyme; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007753316,0.0001262893,0.000292178,0.00006153751,0.00001881939,0.000006955209,0.0001222393,0.0001867005,0.00009185171],"category_scores_gemma":[0.00003879252,0.0001006703,0.00007000773,0.00009021032,0.00008096141,0.00001573837,0.00003046097,0.0001366626,2.624813e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006880597,"about_ca_system_score_gemma":0.00001933354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004596315,"about_ca_topic_score_gemma":0.00001630845,"domain_scores_codex":[0.9990824,0.00008653189,0.0004431094,0.0001772141,0.00007360822,0.0001371624],"domain_scores_gemma":[0.9993654,0.000005989683,0.0003236581,0.00009445592,0.00009836882,0.0001121341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005096516,0.000009894266,0.04326693,0.00003682349,0.00002775605,0.000008289967,0.0001704937,0.000006527728,0.9545359,0.00003188274,0.000003593622,0.001392226],"study_design_scores_gemma":[0.001349034,0.002164497,0.5244926,0.00001799442,0.00006257446,0.00008659707,0.00004400821,0.0002970145,0.4685197,0.0003500848,0.002404853,0.0002109879],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986646,0.0003181053,0.0004022545,0.00031718,0.0001203669,0.0001001629,0.00006755275,0.000002051145,0.000007735387],"genre_scores_gemma":[0.9976804,0.0002009605,0.0005906725,0.0002640973,0.0004001516,5.766666e-7,0.0008455741,0.00001107156,0.000006557654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4860162,"threshold_uncertainty_score":0.4105217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129361784292807,"score_gpt":0.2401661845529179,"score_spread":0.2288725667099898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}