{"id":"W3045191419","doi":"10.3390/cells9081765","title":"Cholesterol as an Endogenous Ligand of ERRα Promotes ERRα-Mediated Cellular Proliferation and Metabolic Target Gene Expression in Breast Cancer Cells","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Breast cancer; Estrogen receptor; Cancer research; Estrogen; Cancer; Cancer cell; Estrogen-related receptor alpha; Cell growth; Triple-negative breast cancer; Nuclear receptor; Endogeny; Endocrinology; Receptor; Cholesterol; Internal medicine; Biology; Medicine; Transcription factor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001160331,0.0002140751,0.0003199231,0.00004918055,0.0000437055,0.00002708526,0.0001459083,0.000180515,0.00003689738],"category_scores_gemma":[0.00001115617,0.0001994505,0.00005558472,0.0001107373,0.00006808085,0.00001727232,0.00007633113,0.0001070037,0.000005752547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006985519,"about_ca_system_score_gemma":0.000133828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001315531,"about_ca_topic_score_gemma":0.00003057885,"domain_scores_codex":[0.9987242,0.00009338954,0.0003026649,0.000472172,0.0001494083,0.0002581946],"domain_scores_gemma":[0.999328,0.000006180765,0.0001379137,0.0002422971,0.00008149278,0.000204145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001340252,0.0001126035,0.001297317,0.0000638283,0.00002225262,5.583473e-7,0.001091699,0.00009423412,0.9961734,0.000001150491,0.000438389,0.0005705149],"study_design_scores_gemma":[0.001141417,0.0001275543,0.001398192,0.00002027601,0.00003299607,0.000008750828,0.0000826144,0.0001595352,0.9830729,0.000005896114,0.0137431,0.0002068071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928254,0.005350492,0.0001767428,0.00009817534,0.0007715046,0.0004927318,0.0002206884,0.00001298964,0.00005127851],"genre_scores_gemma":[0.9930077,0.002871595,0.0003836735,0.0004255648,0.002971291,0.00005853086,0.0001869439,0.00003701032,0.00005767781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01330471,"threshold_uncertainty_score":0.8133357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131160684381929,"score_gpt":0.2222941682793713,"score_spread":0.210982561435552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}