{"id":"W3045191419","doi":"10.3390/cells9081765","title":"Cholesterol as an Endogenous Ligand of ERRα Promotes ERRα-Mediated Cellular Proliferation and Metabolic Target Gene Expression in Breast Cancer Cells","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Breast cancer; Estrogen receptor; Cancer research; Estrogen; Cancer; Cancer cell; Estrogen-related receptor alpha; Cell growth; Triple-negative breast cancer; Nuclear receptor; Endogeny; Endocrinology; Receptor; Cholesterol; Internal medicine; Biology; Medicine; Transcription factor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000135523,0.0002219759,0.0002894381,0.0002366402,0.0001702077,0.000224953,0.0001007127,0.0001388248,0.001605603],"category_scores_gemma":[0.000094532,0.0001026202,0.0002040976,0.000261094,0.000137921,0.0001009175,0.0001676708,0.0003471045,0.0007605792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157477,"about_ca_system_score_gemma":0.0002229861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009428661,"about_ca_topic_score_gemma":0.002097641,"domain_scores_codex":[0.9998447,0.00003372389,0.00001497248,0.00002901494,0.00004878004,0.00002878695],"domain_scores_gemma":[0.9999518,0.000009267796,0.000009619408,0.000007964934,0.00001263053,0.000008628193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001499995,0.00003399261,0.0002661248,0.0000592537,0.000005022094,0.00006439742,0.00001221531,0.00002345395,0.9973984,0.00005708669,0.0001247837,0.001805387],"study_design_scores_gemma":[0.00004125099,0.0002356917,0.00996164,0.00001438978,0.0000179296,0.0005305628,0.00005487959,0.000702439,0.9815457,0.00006260928,0.006826099,0.000006781647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740801,0.01157596,0.006384533,0.0006559126,0.0001745789,0.00004375954,0.001191511,0.0002338886,0.005659694],"genre_scores_gemma":[0.9799592,0.005292072,0.006029898,0.0002624238,0.00004783985,0.00004609356,0.001718273,0.00003237207,0.006611703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001605603,"threshold_uncertainty_score":0.005371273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131160684381929,"score_gpt":0.2222941682793713,"score_spread":0.210982561435552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}