{"id":"W3045287847","doi":"10.1158/1538-7445.pedca19-ia23","title":"Abstract IA23: Lessons from a rare childhood cancer syndrome on replication repair deficiency and hypermutation","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Somatic hypermutation; Biology; Genetics; Cancer; Carcinogenesis; DNA mismatch repair; Cancer research; Germline; Germline mutation; DNA repair; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"case_report","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"medium","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003108614,0.0008084578,0.0007863576,0.0009481984,0.0005495242,0.0007815034,0.0007607522,0.002616118,0.001320529],"category_scores_gemma":[0.001812929,0.0002670939,0.000466145,0.0004621879,0.0008909077,0.0008567093,0.0006644356,0.003060441,0.0005408899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008630472,"about_ca_system_score_gemma":0.0004766547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002737773,"about_ca_topic_score_gemma":0.002078762,"domain_scores_codex":[0.9997261,0.00004402094,0.00002198797,0.00009732573,0.00005911465,0.00005145932],"domain_scores_gemma":[0.9993844,0.000202891,0.00009002924,0.00004147445,0.00009212784,0.0001890741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0002925574,0.00009592903,0.02824284,0.0002766775,0.0000998311,0.8620849,0.0005701492,0.0005721264,0.00980649,0.006705905,0.03232419,0.05892837],"study_design_scores_gemma":[0.00003879858,0.0001109251,0.01425726,0.000221812,0.00008150409,0.9377523,0.0004097234,0.0006231731,0.002051153,0.005839984,0.03856546,0.00004783918],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7192306,0.08949327,0.01786327,0.1128624,0.007493482,0.0001907026,0.001667526,0.00109505,0.05010374],"genre_scores_gemma":[0.9362254,0.02789877,0.005784773,0.01542023,0.006893401,0.00003418962,0.000451383,0.0001924539,0.007099518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002737773,"threshold_uncertainty_score":0.006261885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1331275531628132,"score_gpt":0.4276906524545066,"score_spread":0.2945630992916933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}