{"id":"W3045303558","doi":"10.1021/acs.cgd.0c00571","title":"Supercritical Carbon Dioxide for Pharmaceutical Co-Crystal Production","year":2020,"lang":"en","type":"article","venue":"Crystal Growth & Design","topic":"Phase Equilibria and Thermodynamics","field":"Engineering","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Killam Trusts; Canada Foundation for Innovation","keywords":"Micronization; Crystallization; Solubility; Supercritical fluid; Chemical engineering; Materials science; Solvent; Biopharmaceutics Classification System; Supercritical carbon dioxide; Yield (engineering); Dissolution; Chemistry; Organic chemistry; Metallurgy; Particle size","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005785796,0.0005172394,0.0005698438,0.001299112,0.0004002397,0.0005427263,0.0004816047,0.0005696266,0.002815546],"category_scores_gemma":[0.000515633,0.0002865955,0.0005762,0.001766023,0.0003379181,0.0006984593,0.0005813831,0.001030596,0.002077624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007715435,"about_ca_system_score_gemma":0.0008974228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001549769,"about_ca_topic_score_gemma":0.003816064,"domain_scores_codex":[0.9991416,0.0000799805,0.00005843774,0.0001311221,0.0005425173,0.00004624635],"domain_scores_gemma":[0.9997663,0.00005910586,0.0000507595,0.00002978516,0.00007982804,0.00001421289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001682127,0.0001554331,0.0006050125,0.005392179,0.0001033922,0.0004408834,0.0001266234,0.003280225,0.7712895,0.009654823,0.01013455,0.1986491],"study_design_scores_gemma":[0.00003028595,0.0002655682,0.001321399,0.0002867506,0.00007107545,0.0005367679,0.00004028125,0.005467697,0.7681441,0.001629598,0.2221553,0.00005116913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2004136,0.389654,0.2684459,0.001980876,0.001884238,0.001221759,0.004563096,0.00296172,0.1288748],"genre_scores_gemma":[0.7287087,0.1577259,0.08820499,0.0005399721,0.0004974721,0.0007856652,0.003102972,0.0004528149,0.01998149],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002815546,"threshold_uncertainty_score":0.009418964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03969526164540415,"score_gpt":0.2676826629852862,"score_spread":0.227987401339882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}